PUBLICATION

Disease Modeling of Rare Neurological Disorders in Zebrafish

Authors
Son, M., Kim, D.Y., Kim, C.H.
ID
ZDB-PUB-220413-16
Date
2022
Source
International Journal of Molecular Sciences   23(7): (Review)
Registered Authors
Kim, Cheol-Hee
Keywords
Danio rerio, model organisms, neurological rare diseases, rare diseases, undiagnosed diseases, zebrafish
MeSH Terms
  • Animals
  • Disease Models, Animal
  • Humans
  • Nervous System Diseases*/genetics
  • Neurodevelopmental Disorders*
  • Rare Diseases
  • Zebrafish/genetics
PubMed
35409306 Full text @ Int. J. Mol. Sci.
Abstract
Rare diseases are those which affect a small number of people compared to the general population. However, many patients with a rare disease remain undiagnosed, and a large majority of rare diseases still have no form of viable treatment. Approximately 40% of rare diseases include neurologic and neurodevelopmental disorders. In order to understand the characteristics of rare neurological disorders and identify causative genes, various model organisms have been utilized extensively. In this review, the characteristics of model organisms, such as roundworms, fruit flies, and zebrafish, are examined, with an emphasis on zebrafish disease modeling in rare neurological disorders.
Genes / Markers
Figures
Figure Gallery
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes