Disease Modeling of Rare Neurological Disorders in Zebrafish
- Son, M., Kim, D.Y., Kim, C.H.
- International Journal of Molecular Sciences 23(7): (Review)
- Registered Authors
- Kim, Cheol-Hee
- Danio rerio, model organisms, neurological rare diseases, rare diseases, undiagnosed diseases, zebrafish
- MeSH Terms
- Disease Models, Animal
- Nervous System Diseases*/genetics
- Neurodevelopmental Disorders*
- Rare Diseases
- 35409306 Full text @ Int. J. Mol. Sci.
Son, M., Kim, D.Y., Kim, C.H. (2022) Disease Modeling of Rare Neurological Disorders in Zebrafish. International Journal of Molecular Sciences. 23(7):.
Rare diseases are those which affect a small number of people compared to the general population. However, many patients with a rare disease remain undiagnosed, and a large majority of rare diseases still have no form of viable treatment. Approximately 40% of rare diseases include neurologic and neurodevelopmental disorders. In order to understand the characteristics of rare neurological disorders and identify causative genes, various model organisms have been utilized extensively. In this review, the characteristics of model organisms, such as roundworms, fruit flies, and zebrafish, are examined, with an emphasis on zebrafish disease modeling in rare neurological disorders.
Genes / Markers
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Engineered Foreign Genes
Errata and Notes