PUBLICATION

Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases

Authors
Dai, Y.T., Zhang, F., Fang, H., Li, J.F., Lu, G., Jiang, L., Chen, B., Mao, D.D., Liu, Y.F., Wang, J., Peng, L.J., Feng, C., Chen, H.F., Mu, J.X., Zhang, Q.L., Wang, H., Ariffin, H., Moy, T.A., Wang, J.H., Lou, Y.J., Chen, S.N., Wang, Q., Liu, H., Shan, Z., Matsumura, I., Miyazaki, Y., Yasuda, T., Dou, L.P., Yan, X.J., Yan, J.S., Yeoh, A.E., Wu, D.P., Kiyoi, H., Hayakawa, F., Jin, J., Wang, S.Y., Sun, X.J., Mi, J.Q., Chen, Z., Huang, J.Y., Chen, S.J.
ID
ZDB-PUB-220411-2
Date
2022
Source
Proceedings of the National Academy of Sciences of the United States of America   119: e2120787119 (Journal)
Registered Authors
Chen, Zhu, Sun, Xiao-Jian, Zhang, Fan
Keywords
RNA sequencing, T cell differentiation stages, T-ALL, molecular subtyping, mutation
MeSH Terms
  • Humans
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/genetics
  • Mutation
  • Transcriptome*
  • Child
PubMed
35385357 Full text @ Proc. Natl. Acad. Sci. USA
Abstract
SignificanceWe provide transcriptomic insights into differences between pediatric and adult T cell acute lymphoblastic leukemia (T-ALL) patients through an international collaborative effort integrating RNA-sequencing data of 707 patients. Ten subtypes were identified, each characterized by distinct gene mutation profiles and dysregulated expression signatures of leukemogenic factors, and associated with T cell development stages. Adult T-ALL tends to have characteristics of early T cell precursor ALL, mostly corresponding to the mixed phenotype acute leukemia, whereas pediatric T-ALL shows a wide spectrum of aberrant molecular features, from early T cell precursor to mature T cell compartments. Our findings have important implications for disease mechanism of T-ALL that differs between pediatric and adult patients, facilitating further refined targeted therapy.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
No data available
Human Disease / Model
Human Disease Fish Conditions Evidence
acute lymphoblastic leukemiaTAS
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Sequence Targeting Reagents
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Fish
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Antibodies
No data available
Orthology
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Engineered Foreign Genes
No data available
Mapping
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Citation
Dai, Y.T., Zhang, F., Fang, H., Li, J.F., Lu, G., Jiang, L., Chen, B., Mao, D.D., Liu, Y.F., Wang, J., Peng, L.J., Feng, C., Chen, H.F., Mu, J.X., Zhang, Q.L., Wang, H., Ariffin, H., Moy, T.A., Wang, J.H., Lou, Y.J., Chen, S.N., Wang, Q., Liu, H., Shan, Z., Matsumura, I., Miyazaki, Y., Yasuda, T., Dou, L.P., Yan, X.J., Yan, J.S., Yeoh, A.E., Wu, D.P., Kiyoi, H., Hayakawa, F., Jin, J., Wang, S.Y., Sun, X.J., Mi, J.Q., Chen, Z., Huang, J.Y., Chen, S.J. (2022) Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases. Proceedings of the National Academy of Sciences of the United States of America. 119:e2120787119.