PUBLICATION
Macrophage membrane camouflaged reactive oxygen species responsive nanomedicine for efficiently inhibiting the vascular intimal hyperplasia
- Authors
- Liu, B., Yan, W., Luo, L., Wu, S., Wang, Y., Zhong, Y., Tang, D., Maruf, A., Yan, M., Zhang, K., Qin, X., Qu, K., Wu, W., Wang, G.
- ID
- ZDB-PUB-220315-36
- Date
- 2021
- Source
- Journal of nanobiotechnology 19: 374 (Journal)
- Registered Authors
- Wang, Guixue, Wang, Yi
- Keywords
- Intimal hyperplasia, Macrophages, Nanomedicine, ROS-responsive, Targeted delivery
- MeSH Terms
-
- Animals
- Biomimetic Materials/chemistry
- Biomimetic Materials/pharmacokinetics
- Biomimetic Materials/pharmacology
- Cell Membrane/chemistry
- Cell Proliferation/drug effects
- Cell Survival/drug effects
- Hyperplasia/metabolism*
- Macrophages/cytology*
- Male
- Mice
- Mice, Inbred C57BL
- Nanoparticle Drug Delivery System*/chemistry
- Nanoparticle Drug Delivery System*/metabolism
- Reactive Oxygen Species/metabolism*
- Sirolimus/chemistry
- Sirolimus/pharmacokinetics
- Sirolimus/pharmacology
- Tunica Intima*/drug effects
- Tunica Intima*/metabolism
- Zebrafish
- PubMed
- 34789284 Full text @ J Nanobiotechnology
Citation
Liu, B., Yan, W., Luo, L., Wu, S., Wang, Y., Zhong, Y., Tang, D., Maruf, A., Yan, M., Zhang, K., Qin, X., Qu, K., Wu, W., Wang, G. (2021) Macrophage membrane camouflaged reactive oxygen species responsive nanomedicine for efficiently inhibiting the vascular intimal hyperplasia. Journal of nanobiotechnology. 19:374.
Abstract
Background Intimal hyperplasia caused by vascular injury is an important pathological process of many vascular diseases, especially occlusive vascular disease. In recent years, Nano-drug delivery system has attracted a wide attention as a novel treatment strategy, but there are still some challenges such as high clearance rate and insufficient targeting.
Results In this study, we report a biomimetic ROS-responsive MM@PCM/RAP nanoparticle coated with macrophage membrane. The macrophage membrane with the innate "homing" capacity can superiorly regulate the recruitment of MM@PCM/RAP to inflammatory lesion to enhance target efficacy, and can also disguise MM@PCM/RAP nanoparticle as the autologous cell to avoid clearance by the immune system. In addition, MM@PCM/RAP can effectively improve the solubility of rapamycin and respond to the high concentration level of ROS accumulated in pathological lesion for controlling local cargo release, thereby increasing drug availability and reducing toxic side effects.
Conclusions Our findings validate that the rational design, biomimetic nanoparticles MM@PCM/RAP, can effectively inhibit the pathological process of intimal injury with excellent biocompatibility.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping