PUBLICATION
Gain of gene regulatory network interconnectivity at the origin of vertebrates
- Authors
- Gil-Gálvez, A., Jiménez-Gancedo, S., Pérez-Posada, A., Franke, M., Acemel, R.D., Lin, C.Y., Chou, C., Su, Y.H., Yu, J.K., Bertrand, S., Schubert, M., Escrivá, H., Tena, J.J., Gómez-Skarmeta, J.L.
- ID
- ZDB-PUB-220311-7
- Date
- 2022
- Source
- Proceedings of the National Academy of Sciences of the United States of America 119: e2114802119 (Journal)
- Registered Authors
- Bertrand, Stéphanie, Gómez-Skarmeta, José Luis, Schubert, Michael, Tena, Juan
- Keywords
- amphioxus, evolution, regulatory network, signaling pathway, zebrafish
- Datasets
- GEO:GSE148782, GEO:GSE148781, GEO:GSE148783
- MeSH Terms
-
- Animals
- Biological Evolution
- Gastrulation/genetics
- Gene Expression Regulation, Developmental*
- Gene Regulatory Networks*
- Lancelets*/embryology
- Lancelets*/genetics
- Zebrafish*/embryology
- Zebrafish*/genetics
- PubMed
- 35263228 Full text @ Proc. Natl. Acad. Sci. USA
Citation
Gil-Gálvez, A., Jiménez-Gancedo, S., Pérez-Posada, A., Franke, M., Acemel, R.D., Lin, C.Y., Chou, C., Su, Y.H., Yu, J.K., Bertrand, S., Schubert, M., Escrivá, H., Tena, J.J., Gómez-Skarmeta, J.L. (2022) Gain of gene regulatory network interconnectivity at the origin of vertebrates. Proceedings of the National Academy of Sciences of the United States of America. 119:e2114802119.
Abstract
SignificanceIn this manuscript, we address an essential question in developmental and evolutionary biology: How have changes in gene regulatory networks contributed to the invertebrate-to-vertebrate transition? To address this issue, we perturbed four signaling pathways critical for body plan formation in the cephalochordate amphioxus and in zebrafish and compared the effects of such perturbations on gene expression and gene regulation in both species. Our data reveal that many developmental genes have gained response to these signaling pathways in the vertebrate lineage. Moreover, we show that the interconnectivity between these pathways is much higher in zebrafish than in amphioxus. We conclude that this increased signaling pathway complexity likely contributed to vertebrate morphological novelties during evolution.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping