PUBLICATION

Identification of Scd5 as a functional regulator of visceral fat deposition and distribution

Authors
Zhang, Q., Sun, S., Zhang, Y., Wang, X., Li, Q.
ID
ZDB-PUB-220308-14
Date
2022
Source
iScience   25: 103916 (Journal)
Registered Authors
Li, Qiang, Wang, Xu
Keywords
Genetics, Molecular biology, Molecular genetics
MeSH Terms
none
PubMed
35252813 Full text @ iScience
Abstract
Ectopic deposition of visceral adipose tissue (VAT) in abdomen is usually accompanied with systematic chaos of energy metabolism, a higher risk of cardiovascular diseases and type II diabetes. Here, we identified a previously unexplored gene Scd5 as a master regulator of fat distribution, which alone plays a significant role in determining the VAT accumulation. Firstly, zebrafish scd5 had the highest homology with human SCD5 compared to other SCDs in mouse and rat. We then observed that scd5-homozygous mutant zebrafish displayed a puffy, short and rounded apple-shaped figure. Whole-mount micro-CT scan showed that excessive VAT deposition and short spine are responsible for the abnormal body ratio. And the supplementation of ω3-polyunsaturated fatty acid (ω3-PUFA) in dietary significantly decreased VAT accumulation in scd5-/- zebrafish. Lastly, transcriptional analyses revealed that the Wnt, PPAR, C/EBP, and fat synthesis signaling pathways are significantly affected in the VAT of scd5-/- mutant and restored by ω3-PUFA.
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Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes