PUBLICATION
Design and construction of IR780- and EGCG-based and mitochondrial targeting nanoparticles and their application in tumor chemo-phototherapy
- Authors
- Bao, J., Zhao, Y., Xu, J., Guo, Y.
- ID
- ZDB-PUB-220225-1
- Date
- 2021
- Source
- Journal of materials chemistry. B 9: 9932-9945 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Antineoplastic Agents/chemical synthesis
- Antineoplastic Agents/chemistry
- Antineoplastic Agents/pharmacology*
- Catechin/analogs & derivatives*
- Catechin/chemistry
- Catechin/pharmacology
- Cell Line, Tumor
- Cell Proliferation/drug effects
- Cell Survival/drug effects
- Drug Design
- Drug Screening Assays, Antitumor
- Fluorescent Dyes/chemical synthesis
- Fluorescent Dyes/chemistry
- Fluorescent Dyes/pharmacology*
- Humans
- Indoles/chemistry
- Indoles/pharmacology*
- Iodides/chemistry
- Iodides/pharmacology*
- Materials Testing
- Mitochondria/drug effects
- Mitochondria/metabolism
- Molecular Structure
- Nanoparticles/chemistry
- Neoplasms, Experimental/drug therapy
- Neoplasms, Experimental/metabolism
- Neoplasms, Experimental/pathology
- Photosensitizing Agents/chemical synthesis
- Photosensitizing Agents/chemistry
- Photosensitizing Agents/pharmacology*
- Photothermal Therapy*
- Zebrafish
- PubMed
- 34842269 Full text @ J Mater Chem B
Citation
Bao, J., Zhao, Y., Xu, J., Guo, Y. (2021) Design and construction of IR780- and EGCG-based and mitochondrial targeting nanoparticles and their application in tumor chemo-phototherapy. Journal of materials chemistry. B. 9:9932-9945.
Abstract
An integration combination of phototherapy and chemotherapy to treat carcinoma, solving the inner limitation of individual-modal chemical agent-based therapy or phototherapy, emerges to be a strategy with high prospects for achieving synergistic curative effects. The dye IR780-iodide (IR780) close to infrared radiation is a phototherapy agent with high prospects. However, it is limited in its clinical applications due to poor solubility in water. While epigallocatechin-3-gallate (EGCG), naturally resourced green tea polyphenol, has been extensively proven with intrinsic antitumor activity, but it is largely restricted by its low bioavailability in vivo. Hence, novel multiple-function nanoparticles comprising hyaluronic acid (HA) and IR780 were proposed to deliver EGCG, defined as EGCG@THSI nano-scale particles (EGCG@THSI NPs), thereby rapidly solving limitations of EGCG and IR780. Amphiphilic nano-scale carrier was prepared by triphenylphosphine (TPP), hyaluronic acid (HA), cystamine, and IR780, termed as TPP-HA-SS-IR780, and EGCG was loaded into the amphiphilic copolymer by self-assembly. TPP-HA-SS-IR780 endowed the as-synthesized EGCG@THSI NPs with excellent TPP-mediated mitochondrial-targeted and glutathione-triggered rapid drug release properties. As impacted by the integration of phototherapy and chemotherapy, the EGCG@THSI NPs under NIR laser irradiation showed a prominent anti-tumor effect. Taken together, this study presented a multiple-function nano-scale carrier platform with high prospects in improving the therapeutic efficacy of anti-carcinoma drugs.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping