PUBLICATION
Fecal transplantation from young zebrafish donors efficiently ameliorates the lipid metabolism disorder of aged recipients exposed to perfluorobutanesulfonate
- Authors
- Hu, C., Sun, B., Liu, M., Yu, J., Zhou, X., Chen, L.
- ID
- ZDB-PUB-220215-4
- Date
- 2022
- Source
- The Science of the total environment 823: 153758 (Journal)
- Registered Authors
- Keywords
- Aging, Gut-liver axis, Lipid metabolism, PFBS, Young fecal transplantation, Zebrafish
- MeSH Terms
-
- Animals
- Fecal Microbiota Transplantation
- Female
- Fluorocarbons
- Lipid Metabolism
- Lipid Metabolism Disorders*
- Probiotics*/pharmacology
- Sulfonic Acids
- Zebrafish
- PubMed
- 35151729 Full text @ Sci. Total Environ.
Citation
Hu, C., Sun, B., Liu, M., Yu, J., Zhou, X., Chen, L. (2022) Fecal transplantation from young zebrafish donors efficiently ameliorates the lipid metabolism disorder of aged recipients exposed to perfluorobutanesulfonate. The Science of the total environment. 823:153758.
Abstract
Aging is a biological process that is accompanied by the gradual loss of physiological functions. Under the context of ubiquitous and persistent environmental pollution, the elderly will be more vulnerable to the detrimental effects of toxic pollutants than the young. With objectives to explore effective measures to ameliorate the double stress of aging and toxicants, the present study transplanted the feces from young zebrafish donors to aged recipients, which were concurrently exposed to perfluorobutanesulfonate (PFBS), an emerging environmental pollutant of international concern. After exposure, growth, hepatic structural organization, and lipid metabolism were examined. The results showed that, irrespective of PFBS toxicity, transplantation of young feces significantly enhanced the growth of the aged. In the livers of aged and PFBS-exposed zebrafish, vacuolization symptom was prevalently observed, while young fecal transplantation alleviated the structural defects in aged livers. In the gut of the elderly, digestive activity of lipids was promoted after the transplantation of young feces. The blood of the aged females accumulated significantly higher concentration of triglyceride (TG) than the young counterparts (2.6-fold), implying that the elderly were at high risk of cardiovascular diseases. PFBS treatment of the aged further increased blood TG levels by 2.0-fold relative to the aged control group, pointing to the aggravation of the health of the elderly by environmental pollution. However, it is intriguing that young fecal transplantation efficiently inhibited the metabolic toxicity of PFBS and restored the normal level of blood TG, which provided more evidence about the benefit of young fecal transplant to improve the health of the aged individuals. In the aged livers transplanted with young feces, mitochondrial β-oxidation of fatty acids was consistently activated. Overall, the present study verified the efficacy of young fecal transplantation to mitigate the metabolic disorders resulting from aging and an environmental pollutant.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping