PUBLICATION
Intertissue mechanical interactions shape the olfactory circuit in zebrafish
- Authors
- Monnot, P., Gangatharan, G., Baraban, M., Pottin, K., Cabrera, M., Bonnet, I., Breau, M.A.
- ID
- ZDB-PUB-211214-38
- Date
- 2021
- Source
- EMBO reports 23(2): e52963 (Journal)
- Registered Authors
- Baraban, Marion, Breau, Marie, Gangatharan, Girisaran, Monnot, Pauline
- Keywords
- extracellular matrix, eye, mechanical force, olfactory circuit, placode
- MeSH Terms
-
- Animals
- Axons/physiology
- Ectoderm
- Morphogenesis
- Neurogenesis
- Olfactory Pathways*/anatomy & histology
- Olfactory Pathways*/physiology
- Zebrafish*/anatomy & histology
- Zebrafish*/physiology
- PubMed
- 34889034 Full text @ EMBO Rep.
Citation
Monnot, P., Gangatharan, G., Baraban, M., Pottin, K., Cabrera, M., Bonnet, I., Breau, M.A. (2021) Intertissue mechanical interactions shape the olfactory circuit in zebrafish. EMBO reports. 23(2):e52963.
Abstract
While the chemical signals guiding neuronal migration and axon elongation have been extensively studied, the influence of mechanical cues on these processes remains poorly studied in vivo. Here, we investigate how mechanical forces exerted by surrounding tissues steer neuronal movements and axon extension during the morphogenesis of the olfactory placode in zebrafish. We mainly focus on the mechanical contribution of the adjacent eye tissue, which develops underneath the placode through extensive evagination and invagination movements. Using quantitative analysis of cell movements and biomechanical manipulations, we show that the developing eye exerts lateral traction forces on the olfactory placode through extracellular matrix, mediating proper morphogenetic movements and axon extension within the placode. Our data shed new light on the key participation of intertissue mechanical interactions in the sculpting of neuronal circuits.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping