PUBLICATION
Mechanisms underlying microglial colonization of developing neural retina in zebrafish
- Authors
- Ranawat, N., Masai, I.
- ID
- ZDB-PUB-211211-1
- Date
- 2021
- Source
- eLIFE 10: (Journal)
- Registered Authors
- Masai, Ichiro, Ranawat, Nishtha
- Keywords
- blood vessel, developmental biology, microglia, neurogenesis, neuroscience, retina, zebrafish
- MeSH Terms
-
- Animals
- Cell Movement
- Microglia/cytology
- Microglia/physiology*
- Neurogenesis/physiology
- Retina/cytology
- Retina/growth & development*
- Retinal Vessels
- Stem Cells/cytology
- Zebrafish/growth & development*
- PubMed
- 34872632 Full text @ Elife
Citation
Ranawat, N., Masai, I. (2021) Mechanisms underlying microglial colonization of developing neural retina in zebrafish. eLIFE. 10:.
Abstract
Microglia are brain-resident macrophages that function as the first line of defense in brain. Embryonic microglial precursors originate in peripheral mesoderm and migrate into the brain during development. However, the mechanism by which they colonize the brain is incompletely understood. The retina is one of the first brain regions to accommodate microglia. In zebrafish, embryonic microglial precursors use intraocular hyaloid blood vessels as a pathway to migrate into the optic cup via the choroid fissure. Once retinal progenitor cells exit the cell cycle, microglial precursors associated with hyaloid blood vessels start to infiltrate the retina preferentially through neurogenic regions, suggesting that colonization of retinal tissue depends upon the neurogenic state. Along with blood vessels and retinal neurogenesis, IL34 also participates in microglial precursor colonization of the retina. Altogether, CSF receptor signaling, blood vessels, and neuronal differentiation function as cues to create an essential path for microglial migration into developing retina.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping