PUBLICATION
"Plug and Play" Functionalized Erythrocyte Nanoplatform for Target Atherosclerosis Management
- Authors
- Zhong, Y., Qin, X., Wang, Y., Qu, K., Luo, L., Zhang, K., Liu, B., Obaid, E.A.M.S., Wu, W., Wang, G.
- ID
- ZDB-PUB-211123-22
- Date
- 2021
- Source
- ACS applied materials & interfaces 13: 33862-33873 (Journal)
- Registered Authors
- Wang, Guixue
- Keywords
- atherosclerosis, erythrocyte, plug and play, prodrug, target drug delivery
- MeSH Terms
-
- Animals
- Aorta, Abdominal/drug effects
- Aorta, Abdominal/pathology
- Apolipoproteins E/deficiency
- Atherosclerosis/drug therapy*
- Atherosclerosis/pathology
- Cell Engineering/methods
- Cell Line
- Cell Proliferation/drug effects
- Docetaxel/chemistry
- Docetaxel/therapeutic use*
- Drug Carriers/chemistry*
- Drug Liberation
- Erythrocyte Membrane/chemistry*
- Heart Valves/drug effects
- Heart Valves/pathology
- Humans
- Male
- Mice, Inbred C57BL
- Mice, Knockout
- Oligopeptides/chemistry
- Phosphatidylethanolamines/chemistry*
- Polyethylene Glycols/chemistry*
- Rabbits
- Rats
- Zebrafish
- PubMed
- 34256560 Full text @ ACS Appl. Mater. Interfaces
Citation
Zhong, Y., Qin, X., Wang, Y., Qu, K., Luo, L., Zhang, K., Liu, B., Obaid, E.A.M.S., Wu, W., Wang, G. (2021) "Plug and Play" Functionalized Erythrocyte Nanoplatform for Target Atherosclerosis Management. ACS applied materials & interfaces. 13:33862-33873.
Abstract
For atherosclerosis (AS) management, a therapeutic drug intervention is the most widely used strategy. However, there are some problems such as low location specificity, high intake, and side effects. Nanomedicine can prolong the half-life of drug solubilization, reduce toxic and side effects, and improve the distribution of drug objects. Herein, to overcome the challenges, an erythrocyte-based "plug and play" nanoplatform was developed by incorporating the vascular cell adhesion molecule-1 (VCAM-1) targeting and the acid stimulus responsibility. After the function moieties conjugated with DSPE-PEG, the targeting peptide and the acid-sensitive prodrug were conveniently integrated into red blood cells' surface for enhancing target AS drug delivery and controlling local drug release. As a proof of principle, a plug and play nanoplatform with targeted drug delivery and acid-control drug release is demonstrated, achieving a marked therapeutic effect for AS.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping