PUBLICATION
Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart
- Authors
- Chen, Z., Zhou, Z., Peng, X., Sun, C., Yang, D., Li, C., Zhu, R., Zhang, P., Zheng, L., Tang, C.
- ID
- ZDB-PUB-211110-1
- Date
- 2021
- Source
- The journal of physiological sciences : JPS 71: 33 (Journal)
- Registered Authors
- Zhou, Zuoqiong
- Keywords
- Aerobic exercise, Angiogenesis, Cardioprotective, Fatty acid oxidation, Mitochondrial homeostasis, Physiological cardiac hypertrophy, mTOR signal
- MeSH Terms
-
- Zebrafish*
- Heart
- Myocardium
- Physical Conditioning, Animal*
- Animals
- Cardiomegaly
- Signal Transduction
- PubMed
- 34749643 Full text @ J Physiol Sci
Citation
Chen, Z., Zhou, Z., Peng, X., Sun, C., Yang, D., Li, C., Zhu, R., Zhang, P., Zheng, L., Tang, C. (2021) Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart. The journal of physiological sciences : JPS. 71:33.
Abstract
Herein, we aimed to establish an aerobic exercise-induced physiological myocardial hypertrophy zebrafish (Danio rerio) model and to explore the underlying molecular mechanism. After 4 weeks of aerobic exercise, the AMR and Ucrit of the zebrafish increased and the hearts were enlarged, with thickened myocardium, an increased number of myofilament attachment points in the Z-line, and increased compaction of mitochondrial cristae. We also found that the mTOR signaling pathway, angiogenesis, mitochondrial fusion, and fission event, and mitochondrial autophagy were associated with the adaptive changes in the heart during training. In addition, the increased mRNA expression of genes related to fatty acid oxidation and antioxidation suggested that the switch of energy metabolism and the maintenance of mitochondrial homeostasis induced cardiac physiological changes. Therefore, the zebrafish heart physiological hypertrophy model constructed in this study can be helpful in investigating the cardioprotective mechanisms in response to aerobic exercise.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping