PUBLICATION

Met is required for oligodendrocyte progenitor cell migration in Danio rerio

Authors
Ali, M.F., Latimer, A.J., Wang, Y., Hogenmiller, L., Fontenas, L., Isabella, A.J., Moens, C.B., Yu, G., Kucenas, S.
ID
ZDB-PUB-210928-12
Date
2021
Source
G3 (Bethesda)   11(10): (Journal)
Registered Authors
Ali, Maria, Fontenas, Laura, Kucenas, Sarah, Latimer, Andrew, Moens, Cecilia
Keywords
Met receptor, glial migration, oligodendrocyte progenitor cells, spinal cord development, zebrafish
MeSH Terms
  • Signal Transduction
  • Oligodendrocyte Precursor Cells*
  • Zebrafish
  • Animals
  • Cell Differentiation
  • Spinal Cord
  • Oligodendroglia
(all 7)
PubMed
34568921 Full text @ G3 (Bethesda)
Abstract
During vertebrate central nervous system development, most oligodendrocyte progenitor cells (OPCs) are specified in the ventral spinal cord and must migrate throughout the neural tube until they become evenly distributed, occupying non-overlapping domains. While this process of developmental OPC migration is well characterized, the nature of the molecular mediators that govern it remain largely unknown. Here, using zebrafish as a model, we demonstrate that Met signaling is required for initial developmental migration of OPCs, and, using cell-specific knock-down of Met signaling, show that Met acts cell-autonomously in OPCs. Taken together, these findings demonstrate in vivo, the role of Met signaling in OPC migration and provide new insight into how OPC migration is regulated during development.
Genes / Markers
Figures
Figure Gallery (7 images)
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
No data available
Sequence Targeting Reagents
Target Reagent Reagent Type
metCRISPR2-metCRISPR
metCRISPR3-metCRISPR
metCRISPR4-metCRISPR
metCRISPR5-metCRISPR
metCRISPR6-metCRISPR
metCRISPR7-metCRISPR
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Fish
Antibodies
Orthology
No data available
Engineered Foreign Genes
Marker Marker Type Name
EGFPEFGEGFP
GFPEFGGFP
mRFPEFGmRFP
TagRFPEFGTagRFP
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Mapping
No data available