PUBLICATION
The development of zebrafish pancreas affected by deficiency of Hedgehog signaling
- Authors
- Korzh, S., Winata, C.L., Gong, Z., Korzh, V.
- ID
- ZDB-PUB-210605-13
- Date
- 2021
- Source
- Gene expression patterns : GEP 41: 119185 (Journal)
- Registered Authors
- Gong, Zhiyuan, Korzh, Svitlana, Korzh, Vladimir, Winata, Cecilia Lanny
- Keywords
- annular pancreas, elastase, green fluorescent protein (GFP), pancreas, transgenic, zebrafish
- MeSH Terms
-
- Animals
- Hedgehog Proteins*/genetics
- Pancreas
- Signal Transduction*
- Smoothened Receptor/genetics
- Smoothened Receptor/metabolism*
- Zebrafish*/genetics
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- PubMed
- 34087472 Full text @ Gene Expr. Patterns
Citation
Korzh, S., Winata, C.L., Gong, Z., Korzh, V. (2021) The development of zebrafish pancreas affected by deficiency of Hedgehog signaling. Gene expression patterns : GEP. 41:119185.
Abstract
The pancreas development depends on complex regulation of several signaling pathways, including the Hedgehog (Hh) signaling via a receptor complex component, Smoothened, which deficiency blocks the Hh signaling. Such a defect in birds and mammals results in an annular pancreas. We showed that in developing zebrafish, the mutation of Smoothened or inhibition of Hh signaling by its antagonist cyclopamine caused developmental defects of internal organs, liver, pancreas, and gut. In particular, the pancreatic primordium was duplicated. The two exocrine pancreatic primordia surround the gut. This phenomenon correlates with a significant reduction of the gut's diameter, causing the annular pancreas phenotype.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping