PUBLICATION

Adolescent Idiopathic Scoliosis: Fishy Tales of Crooked Spines

Authors
Roy, S.
ID
ZDB-PUB-210418-2
Date
2021
Source
Trends in genetics : TIG   37(7): 612-615 (Other)
Registered Authors
Keywords
Reissner fiber, UTS2R, Urotensin signaling, adolescent idiopathic scoliosis, cerebrospinal fluid, cilia
MeSH Terms
  • Adolescent
  • Humans
  • Morphogenesis/genetics*
  • Animals
  • Urotensins/cerebrospinal fluid
  • Urotensins/genetics*
  • Cilia/genetics*
  • Cilia/pathology
  • Signal Transduction/genetics
  • Mutation/genetics
  • Spine/pathology
  • Disease Models, Animal
  • Zebrafish/genetics
  • Zebrafish/growth & development
  • Scoliosis/cerebrospinal fluid
  • Scoliosis/genetics*
  • Scoliosis/pathology
(all 17)
PubMed
33858671 Full text @ Trends Genet.
Abstract
Adolescent idiopathic scoliosis (AIS) is a common skeletal disorder, characterized by abnormal spine curvatures. In zebrafish, cilia-driven cerebrospinal fluid flow and urotensin II pathway activity are required for proper spine morphogenesis. Genetic studies with AIS patients now establish a conservation of the zebrafish findings in the etiology of the disease.
Genes / Markers
Figures
No images available
Expression
Phenotype
No data available
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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Citation
Roy, S. (2021) Adolescent Idiopathic Scoliosis: Fishy Tales of Crooked Spines. Trends in genetics : TIG. 37(7):612-615.