PUBLICATION

Ciliary rootlet coiled-coil 2 (crocc2) is associated with evolutionary divergence and plasticity of cichlid jaw shape

Authors
Gilbert, M.C., Tetrault, E., Packard, M., Navon, D., Albertson, R.C.
ID
ZDB-PUB-210316-19
Date
2021
Source
Molecular Biology and Evolution   38(8): 3078-3092 (Journal)
Registered Authors
Albertson, R. Craig
Keywords
cilia, craniofacial, eco-devo, mechanosensing, phenotypic plasticity
MeSH Terms
  • Cichlids/anatomy & histology
  • Cichlids/genetics*
  • Adaptation, Physiological*
  • Female
  • Male
  • Genetic Speciation*
  • Cytoskeletal Proteins/genetics*
  • Animals
  • Jaw/anatomy & histology*
(all 9)
PubMed
33720362 Full text @ Mol Bio Evol
Abstract
Cichlid fishes exhibit rapid, extensive, and replicative adaptive radiation in feeding morphology. Plasticity of the cichlid jaw has also been well documented, and this combination of iterative evolution and developmental plasticity has led to the proposition that the cichlid feeding apparatus represents a morphological "flexible stem". Under this scenario, the fixation of environmentally sensitive genetic variation drives evolutionary divergence along a phenotypic axis established by the initial plastic response. Thus, if plasticity is predictable then so too should be the evolutionary response. We set out to explore these ideas at the molecular level by identifying genes that underlie both the evolution and plasticity of the cichlid jaw. As a first step, we fine-mapped an environment-specific QTL for lower jaw shape in cichlids, and identified a non-synonymous mutation in the ciliary rootlet coiled-coil 2 (crocc2), which encodes a major structural component of the primary cilium. Given that primary cilia play key roles in skeletal mechanosensing, we reasoned that this gene may confer its effects by regulating the sensitivity of bone to respond to mechanical input. Using both cichlids and zebrafish, we confirmed this prediction through a series of experiments targeting multiple levels of biological organization. Taken together, our results implicate crocc2 as a novel mediator of bone formation, plasticity and evolution.
Genes / Markers
Figures
Figure Gallery (7 images)
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Expression
No data available
Phenotype
Fish Conditions Stage Phenotype Figure
crocc2sa20707/sa20707standard conditionsAdult
crocc2sa20707/sa20707standard conditionsAdult
crocc2sa20707/sa20707standard conditionsAdult
crocc2sa20707/sa20707standard conditionsAdult
crocc2sa20707/sa20707standard conditionsAdult
1 - 5 of 5
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Mutations / Transgenics
Allele Construct Type Affected Genomic Region
sa20707
    		Point Mutation
    sa20708
      		Point Mutation
      1 - 2 of 2
      Show
      Human Disease / Model
      No data available
      Sequence Targeting Reagents
      No data available
      Fish
      Fish
      crocc2sa20707/sa20707
      1 - 1 of 1
      Show
      Antibodies
      Orthology
      No data available
      Engineered Foreign Genes
      No data available
      Mapping
      No data available
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      Citation
      Gilbert, M.C., Tetrault, E., Packard, M., Navon, D., Albertson, R.C. (2021) Ciliary rootlet coiled-coil 2 (crocc2) is associated with evolutionary divergence and plasticity of cichlid jaw shape. Molecular Biology and Evolution. 38(8):3078-3092.