PUBLICATION
The possible hormetic effects of fluorene-9-bisphenol on regulating hypothalamic-pituitary-thyroid axis in zebrafish
- Authors
- Jin, M., Dang, J., Paudel, Y.N., Wang, X., Wang, B., Wang, L., Li, P., Sun, C., Liu, K.
- ID
- ZDB-PUB-210228-7
- Date
- 2021
- Source
- The Science of the total environment 776: 145963 (Journal)
- Registered Authors
- Keywords
- BHPF, HPT axis, Hormesis, Thyroid hormone, Zebrafish
- MeSH Terms
-
- Animals
- Benzhydryl Compounds
- Fluorenes
- Phenols
- Plastics
- Thyroid Gland*
- Zebrafish*
- PubMed
- 33639463 Full text @ Sci. Total Environ.
Citation
Jin, M., Dang, J., Paudel, Y.N., Wang, X., Wang, B., Wang, L., Li, P., Sun, C., Liu, K. (2021) The possible hormetic effects of fluorene-9-bisphenol on regulating hypothalamic-pituitary-thyroid axis in zebrafish. The Science of the total environment. 776:145963.
Abstract
Fluorene-9-bisphenol (BHPF) is a bisphenol A substitute, which has been introduced for the production of so-called 'bisphenol A (BPA)-free' plastics. However, it has been reported that BHPF can enter living organisms through using commercial plastic bottles and cause adverse effects. To date, the majority of the toxicologic study of BHPF focused on investigating its doses above the toxicological threshold. Here, we studied the effects of BHPF on development, locomotion, neuron differentiation of the central nervous system (CNS), and the expression of genes in the hypothalamic-pituitary-thyroid (HPT) axis in zebrafish exposed to different doses of BHPF ranging from 1/5 of LD1 to LD50 (300, 500, 750, 1500, 3000, and 4500 nM). As a result, the possible hormetic effects of BHPF on regulating the HPT axis were revealed, in which low-dose BHPF positively affected the HPT axis while this regulation was inhibited as the dose increased. Underlying mechanism investigation suggested that BHPF disrupted myelination through affecting HPT axis including related genes expression and TH levels, thus causing neurotoxic characteristics. Collectively, this study provides the full understanding of the environmental impact of BHPF and its toxicity on living organisms, highlighting a substantial and generalized ongoing dose-response relationship with great implications for the usage and risk assessment of BHPF.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping