The Effects of Copper Constituent of Coin Currency on Embryonic Zebrafish Development
- Hong, T.I., Kang, S.G., Lee, Y.R., Choi, T.I., Kim, W.K., Kim, C.H.
- BioMed Research International 2021: 2134928 (Journal)
- Registered Authors
- Kim, Cheol-Hee
- MeSH Terms
- Embryo, Nonmammalian/drug effects*
- Embryonic Development/drug effects*
- Environmental Exposure/analysis
- Toxicity Tests
- Water Pollutants, Chemical/toxicity*
- 33628775 Full text @ Biomed Res. Int.
Hong, T.I., Kang, S.G., Lee, Y.R., Choi, T.I., Kim, W.K., Kim, C.H. (2021) The Effects of Copper Constituent of Coin Currency on Embryonic Zebrafish Development. BioMed Research International. 2021:2134928.
Copper has demonstrated utility in multiple industrial applications for its high conductivity and antibacterial/antiviral properties. However, numerous findings have suggested potential hazards regarding pathogenesis. This study was conducted to demonstrate the application of zebrafish (Danio rerio) as a cost-effective biological assay to detect environmental pollution, i.e., heavy metal of coins. We demonstrated that zebrafish larvae exposed to copper-plated coins or copper (II) ion solution elicited a consistent phenotype of early mortality without signs of morphological defects in surviving individuals. Copper ion solution served as a standard to (1) corroborate copper exposure from coins and (2) demonstrate proportional increase in early mortality phenotype according to concentration. We found that 5 μM CuSO4·5H2O was the minimal concentration to elicit the observed phenotypes from copper toxicity. This study aimed to demonstrate how a simple protocol involving wild-type zebrafish larvae could provide an economical solution to water monitoring in areas of rapid technological advancement and increasing environmental concerns, especially in communities without access to expensive analytical methods.
Genes / Markers
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Engineered Foreign Genes
Errata and Notes