PUBLICATION
Protective Role of Galanin during Chemically Induced Inflammation in Zebrafish Larvae
- Authors
- Nowik, N., Przyborowska, A., Sienkiewicz, W., Podlasz, P.
- ID
- ZDB-PUB-210213-11
- Date
- 2021
- Source
- Biology 10(2): (Other)
- Registered Authors
- Podlasz, Piotr
- Keywords
- galanin, inflammation, zebrafish
- MeSH Terms
- none
- PubMed
- 33573348 Full text @ Biology (Basel)
Citation
Nowik, N., Przyborowska, A., Sienkiewicz, W., Podlasz, P. (2021) Protective Role of Galanin during Chemically Induced Inflammation in Zebrafish Larvae. Biology. 10(2).
Abstract
During a pathological condition, many different systems are involved in the response of an affected organism. Galanin is considered to be a neuropeptide that plays an important role in the central nervous system; however, it is involved in many other biological processes, including the immune response. During our studies, we showed that galanin became upregulated in zebrafish larvae when exposed to copper sulfate. Moreover, the presence of normal levels of galanin, administration of a galanin analog NAX 5055 or galanin overexpression led to lowered lateral line damage and enhanced expression of inflammatory markers compared to the knockout larvae. The results showed that the neuroendocrine system acts multifunctionally and should be considered as a part of the complex neuro-immune-endocrine axis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping