PUBLICATION
Potential Therapeutic Application of Zinc Oxide Nanoflowers in the Cerebral Ischemia Rat Model through Neuritogenic and Neuroprotective Properties
- Authors
- Barui, A.K., Jhelum, P., Nethi, S.K., Das, T., Bhattacharya, D., B, V., Karri, S., Chakravarty, S., Patra, C.R.
- ID
- ZDB-PUB-210212-11
- Date
- 2020
- Source
- Bioconjugate Chemistry 31: 895-906 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Brain Ischemia/drug therapy*
- Brain Ischemia/metabolism
- Brain Ischemia/pathology
- Cell Line
- Disease Models, Animal
- Nanostructures/chemistry*
- Neurites/drug effects*
- Neurites/pathology
- Neuroprotective Agents/chemistry*
- Neuroprotective Agents/pharmacology*
- Neuroprotective Agents/therapeutic use
- Rats
- Zebrafish
- Zinc Oxide/chemistry*
- Zinc Oxide/pharmacology*
- Zinc Oxide/therapeutic use
- PubMed
- 32050064 Full text @ Bioconjug. Chem.
Citation
Barui, A.K., Jhelum, P., Nethi, S.K., Das, T., Bhattacharya, D., B, V., Karri, S., Chakravarty, S., Patra, C.R. (2020) Potential Therapeutic Application of Zinc Oxide Nanoflowers in the Cerebral Ischemia Rat Model through Neuritogenic and Neuroprotective Properties. Bioconjugate Chemistry. 31:895-906.
Abstract
Neuritogenesis, a complex process of the sprouting of neurites, plays a vital role in the structural and functional restoration of cerebral ischemia-injured neuronal tissue. Practically, there is no effective long-term treatment strategy for cerebral ischemia in clinical practice to date due to several limitations of conventional therapies, facilitating the urgency to develop new alternative therapeutic approaches. Herein, for the first time we report that pro-angiogenic nanomaterials, zinc oxide nanoflowers (ZONF), exhibit neuritogenic activity by elevating mRNA expression of different neurotrophins, following PI3K/Akt-MAPK/ERK signaling pathways. Further, ZONF administration to global cerebral ischemia-induced Fischer rats shows improved neurobehavior and enhanced synaptic plasticity of neurons via upregulation of Neurabin-2 and NT-3, revealing their neuroprotective activity. Altogether, this study offers the basis for exploitation of angio-neural cross talk of other pro-angiogenic nano/biomaterials for future advancement of alternative treatment strategies for cerebral ischemia, where neuritogenesis and neural repair are highly critical.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping