PUBLICATION
Hallmarks of primary neurulation are conserved in the zebrafish forebrain
- Authors
- Werner, J.M., Negesse, M.Y., Brooks, D.L., Caldwell, A.R., Johnson, J.M., Brewster, R.M.
- ID
- ZDB-PUB-210131-7
- Date
- 2021
- Source
- Communications biology 4: 147 (Journal)
- Registered Authors
- Brewster, Rachel
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Cell Movement
- Cell Shape
- Epithelial Cells/metabolism
- Epithelial Cells/physiology*
- Homeodomain Proteins/genetics
- Homeodomain Proteins/metabolism
- Luminescent Proteins/genetics
- Luminescent Proteins/metabolism
- Morphogenesis
- Neural Plate/embryology*
- Neural Plate/metabolism
- Neural Tube/embryology*
- Neural Tube/metabolism
- Neural Tube Defects/embryology
- Neurulation*
- Prosencephalon/embryology*
- Prosencephalon/metabolism
- Recombinant Fusion Proteins/genetics
- Recombinant Fusion Proteins/metabolism
- Time Factors
- Time-Lapse Imaging
- Transcription Factors/genetics
- Transcription Factors/metabolism
- Zebrafish/embryology*
- Zebrafish/genetics
- Zebrafish/metabolism
- PubMed
- 33514864 Full text @ Commun Biol
Citation
Werner, J.M., Negesse, M.Y., Brooks, D.L., Caldwell, A.R., Johnson, J.M., Brewster, R.M. (2021) Hallmarks of primary neurulation are conserved in the zebrafish forebrain. Communications biology. 4:147.
Abstract
Primary neurulation is the process by which the neural tube, the central nervous system precursor, is formed from the neural plate. Incomplete neural tube closure occurs frequently, yet underlying causes remain poorly understood. Developmental studies in amniotes and amphibians have identified hingepoint and neural fold formation as key morphogenetic events and hallmarks of primary neurulation, the disruption of which causes neural tube defects. In contrast, the mode of neurulation in teleosts has remained highly debated. Teleosts are thought to have evolved a unique mode of neurulation, whereby the neural plate infolds in absence of hingepoints and neural folds, at least in the hindbrain/trunk where it has been studied. Using high-resolution imaging and time-lapse microscopy, we show here the presence of these morphological landmarks in the zebrafish anterior neural plate. These results reveal similarities between neurulation in teleosts and other vertebrates and hence the suitability of zebrafish to understand human neurulation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping