PUBLICATION

Polydatin Beneficial Effects in Zebrafish Larvae Undergoing Multiple Stress Types

Authors

Pessina, A., Di Vincenzo, M., Maradonna, F., Marchegiani, F., Olivieri, F., Randazzo, B., Gioacchini, G., Carnevali, O.

ID

ZDB-PUB-210131-3

Date

2021

Source

International Journal of Environmental Research and Public Health 18(3): (Journal)

Registered Authors

Carnevali, Oliana

Keywords

Danio rerio, anti-inflammatory, antioxidant, immune system, interleukins, polyphenols

MeSH Terms

Larva
Stilbenes*/pharmacology
Animals
Zebrafish*
Oxidative Stress
Glucosides/pharmacology

PubMed

33513921 Full text @ Int. J. Environ. Res. Public Health

Abstract

Polydatin is a polyphenol, whose beneficial properties, including anti-inflammatory and antioxidant activity, have been largely demonstrated. At the same time, copper has an important role in the correct organism homeostasis and alteration of its concentration can induce oxidative stress. In this study, the efficacy of polydatin to counteract the stress induced by CuSO₄ exposure or by caudal fin amputation was investigated in zebrafish larvae. The study revealed that polydatin can reduced the stress induced by a 2 h exposure to 10 µM CuSO₄ by lowering the levels of il1b and cxcl8b.1 and reducing neutrophils migration in the head and along the lateral line. Similarly, polydatin administration reduced the number of neutrophils in the area of fin cut. In addition, polydatin upregulates the expression of sod1 mRNA and CAT activity, both involved in the antioxidant response. Most of the results obtained in this study support the working hypothesis that polydatin administration can modulate stress response and its action is more effective in mitigating the effects rather than in preventing chemical damages.

Genes / Markers

Figures