PUBLICATION
Aquatic models of human ciliary diseases
- Authors
- Corkins, M.E., Krneta-Stankic, V., Kloc, M., Miller, R.K.
- ID
- ZDB-PUB-210128-6
- Date
- 2021
- Source
- Genesis (New York, N.Y. : 2000) 59(1-2): e23410 (Review)
- Registered Authors
- Miller, Rachel K
- Keywords
- Xenopus, cilia, ciliopathy, cystic kidney, kidney, nasal, node, zebrafish
- MeSH Terms
-
- Animals
- Ciliopathies/genetics*
- Ciliopathies/metabolism
- Ciliopathies/pathology
- Disease Models, Animal*
- Phenotype
- Xenopus laevis/genetics*
- Xenopus laevis/metabolism
- Zebrafish/genetics*
- Zebrafish/metabolism
- PubMed
- 33496382 Full text @ Genesis
Citation
Corkins, M.E., Krneta-Stankic, V., Kloc, M., Miller, R.K. (2021) Aquatic models of human ciliary diseases. Genesis (New York, N.Y. : 2000). 59(1-2):e23410.
Abstract
Cilia are microtubule-based structures that either transmit information into the cell or move fluid outside of the cell. There are many human diseases that arise from malfunctioning cilia. Although mammalian models provide vital insights into the underlying pathology of these diseases, aquatic organisms such as Xenopus and zebrafish provide valuable tools to help screen and dissect out the underlying causes of these diseases. In this review we focus on recent studies that identify or describe different types of human ciliopathies and outline how aquatic organisms have aided our understanding of these diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping