PUBLICATION
In-vitro and In-vivo Photo-catalytic Cancer Therapy with Bio-compatible Iridium(III) Photo-catalysts
- Authors
- Huang, C., Liang, C., Sadhukhan, T., Banerjee, S., Fan, Z., Li, T., Zhu, Z., Zhang, P., Raghavachari, K., Huang, H
- ID
- ZDB-PUB-210113-7
- Date
- 2021
- Source
- Angewandte Chemie (International ed. in English) 60(17): 9474-9479 (Journal)
- Registered Authors
- Keywords
- metals in medicine bioinorganic chemistry photo catalysis photodynamic therapy NADPH
- MeSH Terms
-
- Animals
- Antineoplastic Agents/chemical synthesis
- Antineoplastic Agents/chemistry
- Antineoplastic Agents/pharmacology*
- Biocompatible Materials/chemical synthesis
- Biocompatible Materials/chemistry
- Biocompatible Materials/pharmacology*
- Catalysis
- Cell Line, Tumor
- Cell Proliferation/drug effects
- Cell Survival/drug effects
- Coordination Complexes/chemical synthesis
- Coordination Complexes/chemistry
- Coordination Complexes/pharmacology*
- Drug Screening Assays, Antitumor
- Humans
- Iridium/chemistry
- Iridium/pharmacology*
- Membrane Potential, Mitochondrial/drug effects
- Mice
- Neoplasms, Experimental/drug therapy
- Neoplasms, Experimental/pathology
- Photochemical Processes
- Photochemotherapy*
- PubMed
- 33434379 Full text @ Angew. Chem. Int. Ed. Engl.
Citation
Huang, C., Liang, C., Sadhukhan, T., Banerjee, S., Fan, Z., Li, T., Zhu, Z., Zhang, P., Raghavachari, K., Huang, H (2021) In-vitro and In-vivo Photo-catalytic Cancer Therapy with Bio-compatible Iridium(III) Photo-catalysts. Angewandte Chemie (International ed. in English). 60(17):9474-9479.
Abstract
Photocatalytic anticancer profile of a Ir(III) photocatalyst ( Ir3 ) with strong light absorption, high turnover frequency, and excellent biocompatibility is reported. Ir3 showed selective photo-cytotoxicity against cisplatin- and sorafenib-resistant cell lines while remaining dormant to normal cell lines in the dark. Ir3 exhibited excellent photo-catalytic oxidation of cellular co-enzyme, the reduced nicotinamide adenine dinucleotide phosphate (NADPH), and amino acids via a single electron transfer mechanism. The photo-induced intracellular redox imbalance and change in mitochondrial membrane potential resulted in necrosis and apoptosis of cancer cells. Importantly, Ir3 exhibited high biocompatibility and photo-catalytic anticancer efficiency as evident from in-vivo zebrafish and mouse cancer models. To the best of our knowledge, Ir3 is the first Ir(III) based photocatalyst with such a high biocompatibility and photocatalytic anticancer therapeutic effect.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping