PUBLICATION
Mechanisms for the impacts of graphene oxide on the developmental toxicity and endocrine disruption induced by bisphenol A on zebrafish larvae
- Authors
- Chen, P., Yang, J., Xiao, B., Zhang, Y., Liu, S., Zhu, L.
- ID
- ZDB-PUB-201229-46
- Date
- 2020
- Source
- Journal of hazardous materials 408: 124867 (Journal)
- Registered Authors
- Keywords
- BPA, E2/T, GO, Transcriptomics, Ultrastructure
- MeSH Terms
-
- Animals
- Benzhydryl Compounds/toxicity
- Ecosystem
- Endocrine Disruptors*/toxicity
- Graphite
- Larva
- Phenols
- Water Pollutants, Chemical*/toxicity
- Zebrafish
- PubMed
- 33370691 Full text @ J. Hazard. Mater.
- CTD
- 33370691
Citation
Chen, P., Yang, J., Xiao, B., Zhang, Y., Liu, S., Zhu, L. (2020) Mechanisms for the impacts of graphene oxide on the developmental toxicity and endocrine disruption induced by bisphenol A on zebrafish larvae. Journal of hazardous materials. 408:124867.
Abstract
The huge production and application of bisphenol A (BPA) and graphene oxide (GO) inevitably lead to their co-presence in aquatic ecosystems, which might cause joint toxic effects to aquatic organisms. Herein, zebrafish larvae at 3 d post fertilization (dpf) were exposed to BPA, GO, and their mixtures until 7 dpf. GO was ingested and localized in the gut. 5000 μg/L BPA alone induced distinct ultrastructure damage, which was alleviated by GO, indicating that GO reduced the developmental toxicity of BPA. The levels of endocrine-related genes and steroid hormones were all modulated to the greatest extent by 500 μg/L BPA, suggesting that BPA exhibited a remarkable endocrine disruption effect. However, the responses of some of these genes were recovered by GO, indicating that GO also alleviated the BPA-induced endocrine disruption. The mRNA levels of five genes in the extracellular matrix-receptor interaction pathway, two in the oxidative phosphorylation pathway, 18 in the metabolic pathways, and five in the peroxisome proliferator-activated receptor signaling pathway were distinctly altered by 5000 μg/L BPA, but most of them were recovered in the presence of GO. GO might relieve the BPA-induced developmental toxicity and endocrine disruption by recovering the genes related to the corresponding pathways.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping