PUBLICATION
Lemnardosinanes A-I: New Bioactive Sesquiterpenoids from Soft Coral Lemnalia sp
- Authors
- Liu, M., Li, P., Tang, X., Luo, X., Liu, K., Zhang, Y., Wang, Q., Li, G.
- ID
- ZDB-PUB-201216-12
- Date
- 2020
- Source
- The Journal of organic chemistry 86(1): 970-979 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Anthozoa*
- China
- Influenza A Virus, H1N1 Subtype*
- Sesquiterpenes*/pharmacology
- Zebrafish
- PubMed
- 33320671 Full text @ J. Org. Chem.
Citation
Liu, M., Li, P., Tang, X., Luo, X., Liu, K., Zhang, Y., Wang, Q., Li, G. (2020) Lemnardosinanes A-I: New Bioactive Sesquiterpenoids from Soft Coral Lemnalia sp. The Journal of organic chemistry. 86(1):970-979.
Abstract
Two rearranged nardosinane sesquiterpenoids with novel carbon skeletons, lemnardosinanes A (1) and B (2), and seven new nardosinane-related sesquiterpeniod lemnardosinanes C-I (3-9), together with a known compound 6,7-seco-13-nornardosinan (10), were isolated from the soft coral Lemnalia sp. collected from Xisha Islands of the South China Sea. Their structures were elucidated by comprehensive spectroscopic analyses, Mosher's method, Mo2(OAc)4-induced circular dichroism experiment, and quantum chemical calculations. Plausible biosynthetic pathways of 1-10 were proposed. Compounds 1 and 10 displayed in vivo angiogenesis promoting activity in a zebrafish model. Compounds 3 and 4 exhibited antiviral activity against the H1N1 virus with IC50 values of 10.9 and 41.5 μM, respectively.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping