PUBLICATION
Effects of cyhalofop-butyl on the developmental toxicity and immunotoxicity in zebrafish (Danio rerio)
- Authors
- Cheng, B., Zou, L., Zhang, H., Cao, Z., Liao, X., Shen, T., Xiong, G., Xiao, J., Liu, H., Lu, H.
- ID
- ZDB-PUB-201212-1
- Date
- 2021
- Source
- Chemosphere 263: 127849 (Journal)
- Registered Authors
- Lu, Huiqiang
- Keywords
- Cyhalofop-butyl, Immunotoxicity, JAK-STAT signaling Pathway, Zebrafish
- MeSH Terms
-
- Animals
- Butanes
- Embryo, Nonmammalian
- Embryonic Development
- Nitriles
- Water Pollutants, Chemical*/toxicity
- Zebrafish*
- PubMed
- 33297003 Full text @ Chemosphere
Citation
Cheng, B., Zou, L., Zhang, H., Cao, Z., Liao, X., Shen, T., Xiong, G., Xiao, J., Liu, H., Lu, H. (2021) Effects of cyhalofop-butyl on the developmental toxicity and immunotoxicity in zebrafish (Danio rerio). Chemosphere. 263:127849.
Abstract
Cyhalofop-butyl is a kind of aromatic phenoxypropionic acid herbicide widely used in agriculture. However, studies on its immunotoxicity to aquatic organisms have not been reported. In this study paper, morphological, immunological, cytological, biochemical and molecular biology methods were used to study the effects of cyhalofop-butyl on the developmental toxicity and immunotoxicity in zebrafish. After cyhalofop-butyl exposed, the results showed that the zebrafish embryos had shorter length, yolk sac edema, significantly reduced number of immune cells, inflammatory response and immunocytes apoptosis. In addition, we found that the expression of immune-related genes and pro-apoptotic genes were up-regulated, and the JAK-STAT signaling pathway mediated the immunotoxicity induced by cyhalofop-butyl. Therefore, our results indicate that cyhalofop-butyl has developmental toxicity and immunotoxicity to zebrafish, and this study offer new contents for the effects of cyhalofop-butyl exposure on aquatic organisms.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping