PUBLICATION

Cadmium chloride-induced transgenerational neurotoxicity in zebrafish development

Authors
Tian, J., Hu, J., Liu, D., Yin, J., Chen, M., Zhou, L., Yin, H.
ID
ZDB-PUB-201120-85
Date
2020
Source
Environmental Toxicology and Pharmacology   81: 103545 (Journal)
Registered Authors
Tian, Jingjing
Keywords
Cadmium chloride, Developmental neurotoxicity, Neurotransmitters, Transgenerational effects, Zebrafish
MeSH Terms
  • Animals
  • Behavior, Animal/drug effects
  • Cadmium Chloride/toxicity*
  • Embryo, Nonmammalian
  • Female
  • Gene Expression Regulation, Developmental/drug effects
  • Male
  • Neurotoxicity Syndromes*/genetics
  • Neurotoxicity Syndromes*/metabolism
  • Neurotoxicity Syndromes*/veterinary
  • Neurotransmitter Agents/metabolism
  • Swimming
  • Water Pollutants, Chemical/toxicity*
  • Zebrafish
PubMed
33171223 Full text @ Environ. Toxicol. Pharmacol.
Abstract
As an important environmental pollutant, the heavy metal cadmium has a significant negative impact on the stability of the ecological environment and on organismal health. Previous studies have shown that cadmium chloride can damage the nervous, skeletal, endocrine, and reproductive systems, but to our knowledge, the effects of cadmium on the behavior, neurotransmitter levels, and neuronal development in the offspring of exposed animals have not been reported. In the present study, sexually-mature zebrafish were exposed to cadmium chloride at different concentrations for 60 days, and in this background, behavior, neurotransmitters level, neuro-development and neurotransmitter metabolism was investigated in the F1 offspring. The results showed that exposure of the parental zebrafish to cadmium chloride resulted swimming speed and distance of F1 offspring significantly reduced; the levels of neurotransmitters, such as dopamine, serotonin, and acetylcholine is disrupted. neuro-development and neurotransmitter metabolism related genes expression pattern was altered, which cause zebrafish F1 offspring developmental neurotoxicity. These findings provide further insights into the harm posed by cadmium chloride to the aquatic ecosystems.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping