PUBLICATION
Molecular evolution of melatonin receptor genes (mtnr) in vertebrates and its shedding light on mtnr1c
- Authors
- Li, Y., Lv, Y., Bian, C., You, X., Shi, Q.
- ID
- ZDB-PUB-201120-73
- Date
- 2020
- Source
- Gene 769: 145256 (Journal)
- Registered Authors
- Keywords
- G protein-coupled receptors, Gene expansion, Gene structure, Genome mining, Melatonin receptor, Molecular evolution
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Evolution, Molecular*
- Receptors, Melatonin/chemistry
- Receptors, Melatonin/classification
- Receptors, Melatonin/genetics*
- Sequence Homology, Amino Acid
- Vertebrates/metabolism*
- PubMed
- 33164759 Full text @ Gene
Citation
Li, Y., Lv, Y., Bian, C., You, X., Shi, Q. (2020) Molecular evolution of melatonin receptor genes (mtnr) in vertebrates and its shedding light on mtnr1c. Gene. 769:145256.
Abstract
Melatonin receptors (MTNRs) play important roles in regulation of circadian rhythms and seasonal reproduction. However, their origin and evolution in vertebrates have not been investigated. Here, we performed a comprehensive examination by comparative genome mining of MTNRs in vertebrates. We successfully extracted 164 putative encoding sequences for MTNRs (including 57 mtnr1a, 59 mtnr1b and 48 mtnr1c) from 45 high-quality representative genomes. Interestingly, the putative expansions of mtnr1a and mtnr1b in zebrafish were also identified in other Cyprinifomes, but not in other orders of teleost. Using phylogenetic interference, we observed this expansion to be clustered into a primitive position of the Actinopterygii, which may be resulted from teleost-specific genome duplication. The C-terminal extension of MTNR1C, predicted to be proteoglycan 4 (PRG4), originated after the speciation of Monotremata or Marsupialia. Our present genomics survey provides novel insights into the evolution of MTNRs in vertebrates and updates our understanding of these proteins.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping