ZFIN ID: ZDB-PUB-201020-4
Zebrafish hhatla is involved in cardiac hypertrophy
Shi, X., Zhang, Y., Gong, Y., Chen, M., Brand-Arzamendi, K., Liu, X., Wen, X.Y.
Date: 2020
Source: Journal of Cellular Physiology   236(5): 3700-3709 (Journal)
Registered Authors: Wen, Xiao-Yan
Keywords: Hhatl, calcineurin, cardiac hypertrophy, hhatla, zebrafish
MeSH Terms:
  • Animals
  • Biomarkers/metabolism
  • Calcineurin/metabolism
  • Cardiomegaly/genetics
  • Cardiomegaly/metabolism*
  • Embryo, Nonmammalian/metabolism
  • Gene Expression Regulation
  • Heart Ventricles/pathology
  • Male
  • Mice, Inbred C57BL
  • Myocardium/pathology
  • Zebrafish/embryology
  • Zebrafish/genetics
  • Zebrafish/metabolism*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
PubMed: 33052609 Full text @ J. Cell. Physiol.
ABSTRACT
Cardiac hypertrophy is a compensatory response to pathological stimuli, ultimately progresses to cardiomyopathy, heart failure, or sudden death. Although many signaling pathways have been reported to be involved in the hypertrophic process, it is still not fully clear about the underlying molecular mechanisms for cardiac hypertrophy. Hedgehog acyltransferase-like (Hhatl), a sarcoplasmic reticulum-resident protein, exhibits high expression in the heart and muscle. However, the biological role of Hhatl in the heart remains unknown. In this study, we first found that the expression level of Hhatl is markedly decreased in cardiac hypertrophy. We further studied the role of hhatla, homolog of Hhatl with the zebrafish model. The depletion of hhatla in zebrafish leads to cardiac defects, as well as an enhanced level of hypertrophic markers. Besides, we found that calcineurin signaling participates in hhatla depletion-induced cardiac hypertrophy. Together, these results demonstrate a critical role for hhatla in cardiac hypertrophy.
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