PUBLICATION

Development of a straight vertebrate body axis

Authors
Bagnat, M., Gray, R.S.
ID
ZDB-PUB-201008-4
Date
2020
Source
Development (Cambridge, England)   147(21): (Review)
Registered Authors
Bagnat, Michel, Gray, Ryan
Keywords
Axis straightening, Notochord, Reissner fiber, Scoliosis, Spine, Vacuoles
MeSH Terms
  • Animals
  • Body Patterning*
  • Morphogenesis
  • Notochord/embryology
  • Scoliosis/embryology
  • Scoliosis/pathology
  • Spine/abnormalities
  • Spine/embryology
  • Spine/pathology
  • Vertebrates/embryology*
PubMed
33023886 Full text @ Development
Abstract
The vertebrate body plan is characterized by the presence of a segmented spine along its main axis. Here, we examine the current understanding of how the axial tissues that are formed during embryonic development give rise to the adult spine and summarize recent advances in the field, largely focused on recent studies in zebrafish, with comparisons to amniotes where appropriate. We discuss recent work illuminating the genetics and biological mechanisms mediating extension and straightening of the body axis during development, and highlight open questions. We specifically focus on the processes of notochord development and cerebrospinal fluid physiology, and how defects in those processes may lead to scoliosis.
Genes / Markers
Figures
Figure Gallery
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Errata and Notes