PUBLICATION
Mitochondria-targeted polydopamine nanoprobes for visualizing endogenous sulfur dioxide derivatives in a rat epilepsy model
- Authors
- Ci, Q., Qin, X., Liu, J., Wang, R., Li, Z., Qin, W., Lim, K.L., Zhang, C.W., Li, L.
- ID
- ZDB-PUB-201007-6
- Date
- 2020
- Source
- Chemical communications (Cambridge, England) 56: 11823-11826 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Epilepsy/metabolism*
- Fluorescent Dyes/chemistry
- Fluorescent Dyes/toxicity
- Hep G2 Cells
- Hippocampus/metabolism
- Humans
- Indoles/chemistry*
- Indoles/toxicity
- Limit of Detection
- Mitochondria/metabolism*
- Polymers/chemistry*
- Polymers/toxicity
- Rats
- Spectrometry, Fluorescence
- Sulfites/analysis*
- Sulfur Dioxide/analysis*
- Sulfur Dioxide/metabolism
- Zebrafish
- PubMed
- 33021257 Full text @ Chem. Commun. (Camb.)
Citation
Ci, Q., Qin, X., Liu, J., Wang, R., Li, Z., Qin, W., Lim, K.L., Zhang, C.W., Li, L. (2020) Mitochondria-targeted polydopamine nanoprobes for visualizing endogenous sulfur dioxide derivatives in a rat epilepsy model. Chemical communications (Cambridge, England). 56:11823-11826.
Abstract
Epilepsy is the fourth most common neurological disorder, and aberrantly elevated sulfur dioxide derivatives (SO32-/HSO3-) are thought to underlie the hippocampal neuronal apoptosis in epilepsy. We have designed and synthesized a mitochondria-targeted polydopamine nanoprobe for visualizing endogenous SO32-/HSO3- by the nucleophilic addition reaction. The nanoprobe was used for imaging SO2 derivatives both in the mitochondria of cultured cells and zebrafish, and successfully applied in the hippocampus of a rat model of epilepsy. The PDAD nanoprobe could be of great value for the elucidation of mechanisms of abnormal SO32-/HSO3- involved in diseases such as epilepsy.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping