PUBLICATION
The low affinity p75 neurotrophin receptor is down-regulated in congenital anomalies of the kidney and the urinary tract: Possible involvement in early nephrogenesis
- Authors
- Fédou, C., Lescat, O., Feuillet, G., Buléon, M., Neau, E., Breuil, B., Alvès, M., Batut, J., Blader, P., Decramer, S., Saulnier-Blache, J.S., Klein, J., Buffin-Meyer, B., Schanstra, J.P.
- ID
- ZDB-PUB-201002-200
- Date
- 2020
- Source
- Biochemical and Biophysical Research Communications 533(4): 786-791 (Journal)
- Registered Authors
- Batut, Julie, Blader, Patrick
- Keywords
- CAKUT, Nephrogenesis, Zebrafish, p75NTR
- MeSH Terms
-
- Animals
- Down-Regulation
- Humans
- Kidney/abnormalities*
- Kidney/embryology*
- Kidney/metabolism
- Mice
- Nerve Tissue Proteins/metabolism*
- Pronephros
- RNA, Messenger/metabolism
- Receptors, Nerve Growth Factor/genetics
- Receptors, Nerve Growth Factor/metabolism*
- Urinary Tract/abnormalities*
- Zebrafish/embryology
- PubMed
- 32988586 Full text @ Biochem. Biophys. Res. Commun.
Citation
Fédou, C., Lescat, O., Feuillet, G., Buléon, M., Neau, E., Breuil, B., Alvès, M., Batut, J., Blader, P., Decramer, S., Saulnier-Blache, J.S., Klein, J., Buffin-Meyer, B., Schanstra, J.P. (2020) The low affinity p75 neurotrophin receptor is down-regulated in congenital anomalies of the kidney and the urinary tract: Possible involvement in early nephrogenesis. Biochemical and Biophysical Research Communications. 533(4):786-791.
Abstract
Congenital Anomalies of the Kidney and of the Urinary Tract (CAKUT) cover a broad range of disorders including abnormal kidney development caused by defective nephrogenesis. Here we explored the possible involvement of the low affinity p75 neurotrophin receptor (p75NTR) in CAKUT and nephrogenesis. In mouse, p75NTR was highly expressed in fetal kidney, located within cortical early nephrogenic bodies, and decreased rapidly after birth. In human control fetal kidney, p75NTR was also located within the early nephrogenic bodies as well as in the mature glomeruli, presumably in the mesangium. In CAKUT fetal kidneys, the kidney cortical structure and the localization of p75NTR were often disorganized, and quantification of p75NTR in amniotic fluid revealed a significant reduction in CAKUT compared to control. Finally, invalidation of p75NTR in zebrafish embryo with an antisense morpholino significantly altered pronephros development. Our results indicate that renal p75NTR is altered in CAKUT fetuses, and could participate to early nephrogenesis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping