PUBLICATION

Is sodium carboxymethyl cellulose (CMC) really completely innocent? It may be triggering obesity

Authors
Baran, A., Sulukan, E., Türko?lu, M., Goshi, A., Yildirim, S., Kankaynar, M., Bolat, ?., Kaya, M., Topal, A., Ceyhun, S.B.
ID
ZDB-PUB-201002-195
Date
2020
Source
International journal of biological macromolecules   163: 2465-2473 (Journal)
Registered Authors
Keywords
Lipid metabolism, Obesity, Oxidative stress, Toxicity, Zebrafish
MeSH Terms
  • Embryo, Nonmammalian
  • Lipid Metabolism/drug effects*
  • Animals
  • Disease Models, Animal
  • Obesity/chemically induced
  • Obesity/metabolism*
  • Sodium/chemistry
  • Carboxymethylcellulose Sodium/adverse effects*
  • Carboxymethylcellulose Sodium/chemistry
  • Food Additives/adverse effects*
  • Food Additives/chemistry
  • Zebrafish/genetics
  • Zebrafish/growth & development
  • Humans
  • Food/adverse effects
(all 15)
PubMed
32987073 Full text @ Int. J. Biol. Macromol.
Abstract
The toxicity of sodium carboxymethyl cellulose (CMC), which has GRAS status and has been determined as "ADI non specified", was re-evaluated with a new modelling and molecular-based data. For this purpose, CMC, a food additive, was injected to the yolk sac (food) of the zebrafish embryo by the microinjection method at the 4th hour of fertilization at different concentrations. As a result, it was found that CMC showed no toxic effects within the framework of the parameters studied. But, we determined increasing lipid accumulation in zebrafish embryos exposed to CMC in a dose-dependent manner. To elucidate the mechanism underlying this lipid accumulation, the expression levels of genes related to obesity-linked lipid metabolism were examined. Our findings show that while CMC does not cause a toxic effect in zebrafish embryos, it can lead important effects on lipid metabolism by causing changes in the expression of some genes associated with obesity.
Genes / Markers
Figures
No images available
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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Citation
Baran, A., Sulukan, E., Türko?lu, M., Goshi, A., Yildirim, S., Kankaynar, M., Bolat, ?., Kaya, M., Topal, A., Ceyhun, S.B. (2020) Is sodium carboxymethyl cellulose (CMC) really completely innocent? It may be triggering obesity. International journal of biological macromolecules. 163:2465-2473.