PUBLICATION
Mechanics as a Means of Information Propagation in Development
- Authors
- Genuth, M.A., Holley, S.A.
- ID
- ZDB-PUB-200905-5
- Date
- 2020
- Source
- BioEssays : news and reviews in molecular, cellular and developmental biology 42(11): e2000121 (Journal)
- Registered Authors
- Holley, Scott
- Keywords
- Drosophila, bmp, cadherin, cell migration, chick, eve1, gastrulation, integrin, intestinal stem cells, myosin, nodal, sonic hedgehog, tailbud, zebrafish
- MeSH Terms
-
- Embryonic Development*
- Morphogenesis
- Signal Transduction*
- PubMed
- 32885468 Full text @ Bioessays
Citation
Genuth, M.A., Holley, S.A. (2020) Mechanics as a Means of Information Propagation in Development. BioEssays : news and reviews in molecular, cellular and developmental biology. 42(11):e2000121.
Abstract
New research demonstrates that mechanics can serve as a means of information propagation in developing embryos. Historically, the study of embryonic development has had a dichotomy between morphogens and pattern formation on the one hand and morphogenesis and mechanics on the other. Secreted signals are the preeminent means of information propagation between cells and used to control cell fate, while physical forces act downstream or in parallel to shape tissue morphogenesis. However, recent work has blurred this division of function by demonstrating that mechanics can serve as a means of information propagation. Adhesive or repulsive interactions can propagate through a tissue as a wave. These waves are rapid and directional and can be used to control the flux of cells through a developmental trajectory. Here, two examples are reviewed in which mechanics both guides and mediates morphogenesis and two examples in which mechanics intertwines with morphogens to regulate cell fate.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping