PUBLICATION
The Zebrafish Dorsolateral Habenula Is Required for Updating Learned Behaviors
- Authors
- Palumbo, F., Serneels, B., Pelgrims, R., Yaksi, E.
- ID
- ZDB-PUB-200828-11
- Date
- 2020
- Source
- Cell Reports 32: 108054 (Journal)
- Registered Authors
- Palumbo, Fabrizio, Pelgrims, Robbrecht, Yaksi, Emre
- Keywords
- behavioral flexibility, cognition, conditioned place avoidance, habenula, learning, memory consolidation, memory extinction, operant conditioning, reversal learning, zebrafish
- MeSH Terms
-
- Zebrafish
- Behavior, Animal/physiology*
- Animals
- Habenula
- PubMed
- 32846116 Full text @ Cell Rep.
Citation
Palumbo, F., Serneels, B., Pelgrims, R., Yaksi, E. (2020) The Zebrafish Dorsolateral Habenula Is Required for Updating Learned Behaviors. Cell Reports. 32:108054.
Abstract
Operant learning requires multiple cognitive processes, such as learning, prediction of potential outcomes, and decision-making. It is less clear how interactions of these processes lead to the behavioral adaptations that allow animals to cope with a changing environment. We show that juvenile zebrafish can perform conditioned place avoidance learning, with improving performance across development. Ablation of the dorsolateral habenula (dlHb), a brain region involved in associative learning and prediction of outcomes, leads to an unexpected improvement in performance and delayed memory extinction. Interestingly, the control animals exhibit rapid adaptation to a changing learning rule, whereas dlHb-ablated animals fail to adapt. Altogether, our results show that the dlHb plays a central role in switching animals' strategies while integrating new evidence with prior experience.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping