PUBLICATION
Larval zebrafish as an in vitro model for evaluating toxicological effects of mycotoxins
- Authors
- Juan-García, A., Bind, M.A., Engert, F.
- ID
- ZDB-PUB-200818-8
- Date
- 2020
- Source
- Ecotoxicology and environmental safety 202: 110909 (Review)
- Registered Authors
- Engert, Florian
- Keywords
- Embryonic development, Embryos, Larvae, Mixtures, Model system, Mycotoxins, Toxicology, Zebrafish
- MeSH Terms
-
- Animals
- Embryo, Nonmammalian/drug effects
- Larva/drug effects
- Mycotoxins/toxicity*
- Teratogens/toxicity
- Water Pollutants, Chemical/toxicity*
- Zebrafish*
- PubMed
- 32800244 Full text @ Ecotoxicol. Environ. Saf.
Citation
Juan-García, A., Bind, M.A., Engert, F. (2020) Larval zebrafish as an in vitro model for evaluating toxicological effects of mycotoxins. Ecotoxicology and environmental safety. 202:110909.
Abstract
The presence of mycotoxins in food has created concern. Mycotoxin prevalence in our environment has changed in the last few years maybe due to climatic and other environmental changes. Evidence has emerged from in vitro and in vivo models: some mycotoxins have been found to be potentially carcinogenic, embryogenically harmful, teratogenic, and to generate nephrotoxicity. The risk assessment of exposures to mycotoxins at early life stages became mandatory. In this regard, the effects of toxic compounds on zebrafish have been widely studied, and more recently, mycotoxins have been tested with respect to their effects on developmental and teratogenic effects in this model system, which offers several advantages as it is an inexpensive and an accessible vertebrate model to study developmental toxicity. External post-fertilization and quick maturation make it sensitive to environmental effects and facilitate the detection of endpoints such as morphological deformities, time of hatching, and behavioral responses. Therefore, there is a potential for larval zebrafish to provide new insights into the toxicological effects of mycotoxins. We provide an overview of recent mycotoxin toxicological research in zebrafish embryos and larvae, highlighting its usefulness to toxicology and discuss the strengths and limitations of this model system.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping