ZFIN ID: ZDB-PUB-200715-14
Neural cells and their progenitors in regenerating zebrafish spinal cord
Hui, S.P., Nag, T.C., Ghosh, S.
Date: 2020
Source: The International journal of developmental biology   64: 363-376 (Journal)
Registered Authors:
Keywords: none
MeSH Terms:
  • Animals
  • Cell Proliferation/physiology
  • Microscopy, Electron, Transmission
  • Neural Stem Cells/cytology
  • Neural Stem Cells/physiology*
  • Neurogenesis/physiology
  • Neuroglia/cytology
  • Neuroglia/physiology
  • Neurons/cytology
  • Neurons/physiology*
  • Oligodendrocyte Precursor Cells/cytology
  • Oligodendrocyte Precursor Cells/physiology
  • Schwann Cells/cytology
  • Schwann Cells/physiology
  • Spinal Cord/cytology
  • Spinal Cord/physiology
  • Spinal Cord/ultrastructure
  • Spinal Cord Injuries/metabolism
  • Spinal Cord Injuries/physiopathology*
  • Spinal Cord Regeneration/physiology*
  • Zebrafish/physiology*
  • Zebrafish Proteins/metabolism
PubMed: 32658995 Full text @ Int. J. Dev. Biol.
ABSTRACT
The zebrafish (Danio rerio), among all amniotes is emerging as a powerful model to study vertebrate organogenesis and regeneration. In contrast to mammals, the adult zebrafish is capable of regenerating damaged axonal tracts; it can replace neurons and glia lost after spinal cord injury (SCI) and functionally recover. In the present paper, we report ultrastructural and cell biological analyses of regeneration processes after SCI. We have focused on event specific analyses of spinal cord regeneration involving different neuronal and glial cell progenitors, such as radial glia, oligodendrocyte progenitors (OPC), and Schwann cells. While comparing the different events, we frequently refer to previous ultrastructural analyses of central nervous system (CNS) injury in higher vertebrates. Our data show (a) the cellular events following injury, such as cell death and proliferation; (b) demyelination and remyelination followed by target innervation and regeneration of synaptic junctions and c) the existence of different progenitors and their roles during regeneration. The present ultrastructural analysis corroborates the cellular basis of regeneration in the zebrafish spinal cord and confirms the presence of both neuronal and different glial progenitors.
ADDITIONAL INFORMATION