|ZFIN ID: ZDB-PUB-200712-11|
A zebrafish model of tuberculosis comorbidity and the effects of HIF-activating intervention
Oehlers, S.H., Hortle, E., Cook, K.M.
|Source:||The FEBS journal 287(18): 3917-3920 (Journal)|
|Registered Authors:||Hortle, Elinor, Oehlers, Stefan|
|Keywords:||hypoxia, inflammation, mycobacteria, mycobacterial, neutrophil|
|PubMed:||32652856 Full text @ FEBS J.|
Oehlers, S.H., Hortle, E., Cook, K.M. (2020) A zebrafish model of tuberculosis comorbidity and the effects of HIF-activating intervention. The FEBS journal. 287(18):3917-3920.
ABSTRACTComorbidities are an important factor in tuberculosis pathophysiology and treatment but are understudied in animal models. Schild et al. present a zebrafish model of Mycobacterium marinum infection and wound comorbidity that retains responsiveness to protective hypoxia-inducible factor-1α activation as an example of a host-directed therapy. This platform is a new paradigm for the zebrafish-M. marinum infection model and provides a blueprint to test therapeutic interventions on infection and comorbid pathologies. Comment on: https://doi.org/10.1111/febs.15433.
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