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ZFIN ID: ZDB-PUB-200712-11
A zebrafish model of tuberculosis comorbidity and the effects of HIF-activating intervention
Oehlers, S.H., Hortle, E., Cook, K.M.
Date: 2020
Source: The FEBS journal   287(18): 3917-3920 (Journal)
Registered Authors: Hortle, Elinor, Oehlers, Stefan
Keywords: hypoxia, inflammation, mycobacteria, mycobacterial, neutrophil
MeSH Terms:
  • Animals
  • Comorbidity
  • Disease Models, Animal
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Mycobacterium Infections, Nontuberculous*
  • Mycobacterium marinum*
  • Tuberculosis*/drug therapy
  • Tuberculosis*/epidemiology
  • Tuberculosis*/prevention & control
  • Zebrafish
PubMed: 32652856 Full text @ FEBS J.
Comorbidities are an important factor in tuberculosis pathophysiology and treatment but are understudied in animal models. Schild et al. present a zebrafish model of Mycobacterium marinum infection and wound comorbidity that retains responsiveness to protective hypoxia-inducible factor-1α activation as an example of a host-directed therapy. This platform is a new paradigm for the zebrafish-M. marinum infection model and provides a blueprint to test therapeutic interventions on infection and comorbid pathologies. Comment on: