PUBLICATION
A zebrafish model of tuberculosis comorbidity and the effects of HIF-activating intervention
- Authors
- Oehlers, S.H., Hortle, E., Cook, K.M.
- ID
- ZDB-PUB-200712-11
- Date
- 2020
- Source
- The FEBS journal 287(18): 3917-3920 (Journal)
- Registered Authors
- Hortle, Elinor, Oehlers, Stefan
- Keywords
- hypoxia, inflammation, mycobacteria, mycobacterial, neutrophil
- MeSH Terms
-
- Animals
- Comorbidity
- Disease Models, Animal
- Hypoxia-Inducible Factor 1, alpha Subunit
- Mycobacterium Infections, Nontuberculous*
- Mycobacterium marinum*
- Tuberculosis*/drug therapy
- Tuberculosis*/epidemiology
- Tuberculosis*/prevention & control
- Zebrafish
- PubMed
- 32652856 Full text @ FEBS J.
Citation
Oehlers, S.H., Hortle, E., Cook, K.M. (2020) A zebrafish model of tuberculosis comorbidity and the effects of HIF-activating intervention. The FEBS journal. 287(18):3917-3920.
Abstract
Comorbidities are an important factor in tuberculosis pathophysiology and treatment but are understudied in animal models. Schild et al. present a zebrafish model of Mycobacterium marinum infection and wound comorbidity that retains responsiveness to protective hypoxia-inducible factor-1α activation as an example of a host-directed therapy. This platform is a new paradigm for the zebrafish-M. marinum infection model and provides a blueprint to test therapeutic interventions on infection and comorbid pathologies. Comment on: https://doi.org/10.1111/febs.15433.
Genes / Markers
Probes
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping