ZFIN ID: ZDB-PUB-200711-2
Studying the Pathophysiology of Parkinson's Disease Using Zebrafish
Barnhill, L.M., Murata, H., Bronstein, J.M.
Date: 2020
Source: Biomedicines   8(7): (Review)
Registered Authors: Barnhill, Lisa, Bronstein, Jeff
Keywords: Parkinson’s disease, dopaminergic neuron, toxins, zebrafish
MeSH Terms: none
PubMed: 32645821 Full text @ Biomedicines
Parkinson's disease is a common neurodegenerative disorder leading to severe disability. The clinical features reflect progressive neuronal loss, especially involving the dopaminergic system. The causes of Parkinson's disease are slowly being uncovered and include both genetic and environmental insults. Zebrafish have been a valuable tool in modeling various aspects of human disease. Here, we review studies utilizing zebrafish to investigate both genetic and toxin causes of Parkinson's disease. They have provided important insights into disease mechanisms and will be of great value in the search for disease-modifying therapies.