PUBLICATION
The lateral plate mesoderm
- Authors
- Prummel, K.D., Nieuwenhuize, S., Mosimann, C.
- ID
- ZDB-PUB-200623-19
- Date
- 2020
- Source
- Development (Cambridge, England) 147(12): (Review)
- Registered Authors
- Mosimann, Christian, Nieuwenhuize, Susan, Prummel, Karin
- Keywords
- Cardiovascular system, Cell fate, Development, Evolution, Gene regulation, Lateral plate mesoderm
- MeSH Terms
-
- Animals
- Cardiovascular System/growth & development
- Cardiovascular System/metabolism
- Cell Differentiation
- Cell Lineage
- Embryonic Development
- Gene Expression Regulation, Developmental
- Humans
- Mesoderm/cytology
- Mesoderm/growth & development*
- Mesoderm/metabolism
- Stem Cells/cytology
- Stem Cells/metabolism
- Transcription Factors/metabolism
- PubMed
- 32561665 Full text @ Development
Citation
Prummel, K.D., Nieuwenhuize, S., Mosimann, C. (2020) The lateral plate mesoderm. Development (Cambridge, England). 147(12):.
Abstract
The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the developing vertebrate embryo. Despite this central role in development and evolution, the LPM remains challenging to study and to delineate, owing to its lineage complexity and lack of a concise genetic definition. Here, we outline the processes that govern LPM specification, organization, its cell fates and the inferred evolutionary trajectories of LPM-derived tissues. Finally, we discuss the development of seemingly disparate organ systems that share a common LPM origin.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping