PUBLICATION

Chromatin dynamics at the maternal to zygotic transition: recent advances from the zebrafish model

Authors
Akdogan-Ozdilek, B., Duval, K.L., Goll, M.G.
ID
ZDB-PUB-200613-7
Date
2020
Source
F1000Research   9: (Review)
Registered Authors
Goll, Mary
Keywords
DNA methylation, chromatin, histones, maternal-to-zygotic transition, transcription, zebrafish
MeSH Terms
  • Animals
  • Chromatin/genetics*
  • Embryo, Nonmammalian*
  • Gene Expression Regulation, Developmental*
  • Zebrafish/embryology*
  • Zebrafish Proteins*
  • Zygote
PubMed
32528656 Full text @ F1000Res
Abstract
Early animal development is characterized by intense reorganization of the embryonic genome, including large-scale changes in chromatin structure and in the DNA and histone modifications that help shape this structure. Particularly profound shifts in the chromatin landscape are associated with the maternal-to-zygotic transition, when the zygotic genome is first transcribed and maternally loaded transcripts are degraded. The accessibility of the early zebrafish embryo facilitates the interrogation of chromatin during this critical window of development, making it an important model for early chromatin regulation. Here, we review our current understanding of chromatin dynamics during early zebrafish development, highlighting new advances as well as similarities and differences between early chromatin regulation in zebrafish and other species.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping