PUBLICATION
Nano-TiO2 enhanced bioaccumulation and developmental neurotoxicity of bisphenol a in zebrafish larvae
- Authors
- Fu, J., Guo, Y., Yang, L., Han, J., Zhou, B.
- ID
- ZDB-PUB-200526-20
- Date
- 2020
- Source
- Environmental research 187: 109682 (Journal)
- Registered Authors
- Yang, LiHua, Zhou, BingSheng
- Keywords
- Bioaccumulation, Bisphenol A, Co-exposure, Neurotoxicity, Zebrafish larvae, n-TiO(2)
- MeSH Terms
-
- Animals
- Benzhydryl Compounds
- Bioaccumulation
- Larva
- Phenols
- Titanium
- Water Pollutants, Chemical*/toxicity
- Zebrafish*
- PubMed
- 32450427 Full text @ Environ. Res.
Citation
Fu, J., Guo, Y., Yang, L., Han, J., Zhou, B. (2020) Nano-TiO2 enhanced bioaccumulation and developmental neurotoxicity of bisphenol a in zebrafish larvae. Environmental research. 187:109682.
Abstract
The titanium dioxide nanoparticles (n-TiO2) could enhance the bioavailability and toxicity of the coexisted organic toxicants in aquatic phase. Parental co-exposure to n-TiO2 and bisphenol A (BPA) could generate developmental neurotoxicity in unexposed zebrafish offspring. However, it remains unexplored regarding the developmental neurotoxicity in larvae fish after co-exposure during the early developmental stage. In present study, fertilized zebrafish eggs were exposed to TiO2 nanoparticles (100 μg/L), BPA (1, 4 and 20 μg/L) or their binary mixtures until 6 days post fertilization (dpf). No significant change was observed in hatching, malformation, survival and weight of the larvae among all groups. However, n-TiO2 significantly increased the body burden of BPA in the 4 and 20 μg/L co-exposure groups, depressed expression of neurodevelopment marker genes (α1-tubulin, mbp and syn2a) as well as the locomotor behavior. The current results indicate that n-TiO2 could strengthen the developmental neurotoxicity and inactive locomotion in co-exposed zebrafish larvae by promoting the bioaccumulation and bioavailability of BPA, which highlighted the similar toxic risks of developmental neurotoxicity after co-exposure at early developmental stage to that of the parental co-exposure.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping