PUBLICATION
Graphene oxide mitigates endocrine disruption effects of bisphenol A on zebrafish at an early development stage
- Authors
- Yang, J., Zhong, W., Chen, P., Zhang, Y., Sun, B., Liu, M., Zhu, Y., Zhu, L.
- ID
- ZDB-PUB-200510-2
- Date
- 2019
- Source
- The Science of the total environment 697: 134158 (Journal)
- Registered Authors
- Keywords
- Bisphenol A, Endocrine disruption, Graphene oxide, Interaction, Zebrafish embryo-larvae
- MeSH Terms
-
- Embryo, Nonmammalian/drug effects*
- Water Pollutants, Chemical/toxicity*
- Endocrine Disruptors/toxicity*
- Graphite/chemistry*
- Zebrafish/embryology*
- Phenols/toxicity*
- Benzhydryl Compounds/toxicity*
- Animals
- PubMed
- 32380620 Full text @ Sci. Total Environ.
Citation
Yang, J., Zhong, W., Chen, P., Zhang, Y., Sun, B., Liu, M., Zhu, Y., Zhu, L. (2019) Graphene oxide mitigates endocrine disruption effects of bisphenol A on zebrafish at an early development stage. The Science of the total environment. 697:134158.
Abstract
Development from embryos to larvae is an important life stage and impairments in this stage could affect the development and growth of fish. In this study, the endocrine disruption and developmental toxicities of bisphenol A (BPA) (50 and 500 μg/L) in the presence of graphene oxide (GO) (0.1 and 1 mg/L) were investigated on zebrafish embryos from 6 to 168 h post fertilization (hpf). BPA alone displayed significant endocrine disruption effects (increase in the estradiol (E2)/testosterone (T) ratio, vitellogenin (VTG) and estrogen receptor α (erα) in larvae), promoted embryos hatching and caused larvae malformation. There was a significant correlation between VTG level and erα expression, suggesting that erα played a vital role in VTG synthesis. However, all these adverse effects were alleviated distinctly in the presence of GO. GO formed a coating layer on the embryos chorion membrane, depressing absorption of BPA by the embryos. As a consequence, bioaccumulation of BPA in zebrafish co-exposed to GO and BPA decreased by >50% compared with the BPA single exposure group. Adsorption of BPA on GO might also make a partial contribution to the reduced accumulation of BPA in the larvae. The results demonstrated that GO could relieve the estrogenic and developmental effects of BPA on zebrafish in the early development stage.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping