PUBLICATION
Optical control of CRAC channels using photoswitchable azopy-razoles
- Authors
- Yang, X., Ma, G., Zheng, S., Qin, X., Li, X., Du, L., Wang, Y., Zhou, Y., Li, M.
- ID
- ZDB-PUB-200426-16
- Date
- 2020
- Source
- Journal of the American Chemical Society 142(20): 9460-9470 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
- none
- PubMed
- 32330031 Full text @ J. Am. Chem. Soc.
Citation
Yang, X., Ma, G., Zheng, S., Qin, X., Li, X., Du, L., Wang, Y., Zhou, Y., Li, M. (2020) Optical control of CRAC channels using photoswitchable azopy-razoles. Journal of the American Chemical Society. 142(20):9460-9470.
Abstract
The Ca2+ release-activated Ca2+ (CRAC) channels control many Ca2+-modulated physiological processes in mammals. Hyperactivating CRAC channels are known to cause Stormorken syndrome. Here we show the design of azopyrazole-derived photoswitchable CRAC channel inhibitors (designated piCRACs), which enable optical inhibition of store-operated Ca2+ influx and downstream signaling. Moreover, piCRAC-1 has been applied in vivo to alleviate thrombocytopenia and hemorrhage in a zebrafish model of Stormorken syndrome in a light-dependent manner.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping