PUBLICATION
Workflow for Comparison of Chemical and Biological Metrics of Filter Collected PM2.5
- Authors
- Roper, C., Perez, A., Barrett, D., Hystad, P., Massey Simonich, S.L., Tanguay, R.L.
- ID
- ZDB-PUB-200422-172
- Date
- 2020
- Source
- Atmospheric environment (Oxford, England : 1994) 226: (Journal)
- Registered Authors
- Tanguay, Robyn L.
- Keywords
- Household air pollution, Indoor PM2.5, PAH diagnostic ratios, PM2.5 composition, oxidative potential, zebrafish
- MeSH Terms
- none
- PubMed
- 32313426 Full text @ Atmos Environ (1994)
Citation
Roper, C., Perez, A., Barrett, D., Hystad, P., Massey Simonich, S.L., Tanguay, R.L. (2020) Workflow for Comparison of Chemical and Biological Metrics of Filter Collected PM2.5. Atmospheric environment (Oxford, England : 1994). 226:.
Abstract
There is limited understanding of adverse health effect associations with chemical constituents of fine particulate matter (PM2.5) as well as the underlying mechanisms. We outlined a workflow to assess metrics, beyond concentration, using household and personal PM2.5 filter samples collected in India as a proof of concept for future large-scale studies. Oxidative potential, chemical composition (polycyclic aromatic hydrocarbons and elements), and bioactivity (developmental exposures in zebrafish) were determined. Significant differences were observed in all metrics between personal and household PM2.5 samples. This work established methods to characterize multiple metrics of PM2.5 to ultimately support the identification of more health-relevant metrics than concentration.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping