PUBLICATION
Using Zebrafish to Analyze the Genetic and Environmental Etiologies of Congenital Heart Defects
- Authors
- Shrestha, R., Lieberth, J., Tillman, S., Natalizio, J., Bloomekatz, J.
- ID
- ZDB-PUB-200422-151
- Date
- 2020
- Source
- Advances in experimental medicine and biology 1236: 189-223 (Chapter)
- Registered Authors
- Bloomekatz, Joshua
- Keywords
- none
- MeSH Terms
-
- Animals
- Environment*
- Gene-Environment Interaction
- Heart/embryology
- Heart Defects, Congenital/embryology
- Heart Defects, Congenital/etiology*
- Heart Defects, Congenital/genetics*
- Heart Defects, Congenital/pathology
- Humans
- Zebrafish/embryology
- Zebrafish/genetics*
- PubMed
- 32304074 Full text @ Adv. Exp. Med. Biol.
Citation
Shrestha, R., Lieberth, J., Tillman, S., Natalizio, J., Bloomekatz, J. (2020) Using Zebrafish to Analyze the Genetic and Environmental Etiologies of Congenital Heart Defects. Advances in experimental medicine and biology. 1236:189-223.
Abstract
Congenital heart defects (CHDs) are among the most common human birth defects. However, the etiology of a large proportion of CHDs remains undefined. Studies identifying the molecular and cellular mechanisms that underlie cardiac development have been critical to elucidating the origin of CHDs. Building upon this knowledge to understand the pathogenesis of CHDs requires examining how genetic or environmental stress changes normal cardiac development. Due to strong molecular conservation to humans and unique technical advantages, studies using zebrafish have elucidated both fundamental principles of cardiac development and have been used to create cardiac disease models. In this chapter we examine the unique toolset available to zebrafish researchers and how those tools are used to interrogate the genetic and environmental contributions to CHDs.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping