ZFIN ID: ZDB-PUB-200403-92
Temporal control of Wnt signaling is required for habenular neuron diversity and brain asymmetry
Guglielmi, L., Bühler, A., Moro, E., Argenton, F., Poggi, L., Carl, M.
Date: 2020
Source: Development (Cambridge, England)   147(6): (Journal)
Registered Authors: Argenton, Francesco, Bühler, Anja, Carl, Matthias, Moro, Enrico, Poggi, Lucia
Keywords: Asymmetry, Brain, Habenula, Wif1, Wnt, Zebrafish
MeSH Terms:
  • Adaptor Proteins, Signal Transducing/genetics
  • Adaptor Proteins, Signal Transducing/metabolism
  • Adaptor Proteins, Signal Transducing/physiology*
  • Animals
  • Animals, Genetically Modified
  • Body Patterning/genetics*
  • Brain/cytology
  • Brain/embryology
  • Cell Differentiation/genetics
  • Cell Lineage/genetics
  • Dominance, Cerebral/genetics
  • Embryo, Nonmammalian
  • Habenula/embryology*
  • Habenula/metabolism
  • Neurogenesis/genetics*
  • Neurogenesis/physiology
  • Neurons/cytology
  • Neurons/physiology*
  • Repressor Proteins/genetics
  • Repressor Proteins/metabolism
  • Repressor Proteins/physiology*
  • Wnt Proteins/genetics
  • Wnt Proteins/metabolism
  • Wnt Signaling Pathway/physiology*
  • Zebrafish/embryology
  • Zebrafish/genetics
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
  • Zebrafish Proteins/physiology*
PubMed: 32179574 Full text @ Development
Precise temporal coordination of signaling processes is pivotal for cellular differentiation during embryonic development. A vast number of secreted molecules are produced and released by cells and tissues, and travel in the extracellular space. Whether they induce a signaling pathway and instruct cell fate, however, depends on a complex network of regulatory mechanisms, which are often not well understood. The conserved bilateral left-right asymmetrically formed habenulae of the zebrafish are an excellent model for investigating how signaling control facilitates the generation of defined neuronal populations. Wnt signaling is required for habenular neuron type specification, asymmetry and axonal connectivity. The temporal regulation of this pathway and the players involved have, however, have remained unclear. We find that tightly regulated temporal restriction of Wnt signaling activity in habenular precursor cells is crucial for the diversity and asymmetry of habenular neuron populations. We suggest a feedback mechanism whereby the tumor suppressor Wnt inhibitory factor Wif1 controls the Wnt dynamics in the environment of habenular precursor cells. This mechanism might be common to other cell types, including tumor cells.