|ZFIN ID: ZDB-PUB-200305-3|
Molecular and cellular determinants of motor asymmetry in zebrafish
Horstick, E.J., Bayleyen, Y., Burgess, H.A.
|Source:||Nature communications 11: 1170 (Journal)|
|Registered Authors:||Burgess, Harold, Horstick, Eric|
|PubMed:||32127541 Full text @ Nat. Commun.|
Horstick, E.J., Bayleyen, Y., Burgess, H.A. (2020) Molecular and cellular determinants of motor asymmetry in zebrafish. Nature communications. 11:1170.
ABSTRACTAsymmetries in motor behavior, such as human hand preference, are observed throughout bilateria. However, neural substrates and developmental signaling pathways that impose underlying functional lateralization on a broadly symmetric nervous system are unknown. Here we report that in the absence of over-riding visual information, zebrafish larvae show intrinsic lateralized motor behavior that is mediated by a cluster of 60 posterior tuberculum (PT) neurons in the forebrain. PT neurons impose motor bias via a projection through the habenular commissure. Acquisition of left/right identity is disrupted by heterozygous mutations in mosaic eyes and mindbomb, genes that regulate Notch signaling. These results define the neuronal substrate for motor asymmetry in a vertebrate and support the idea that haploinsufficiency for genes in a core developmental pathway destabilizes left/right identity.