PUBLICATION

Cadmium exposure reduces the density of a specific ionocyte subtype in developing zebrafish

Authors
Dave, P.H., Kwong, R.W.M.
ID
ZDB-PUB-200214-1
Date
2020
Source
Chemosphere   244: 125535 (Journal)
Registered Authors
Keywords
Cadmium, Ionic regulation, Ionocyte, Zebrafish
MeSH Terms
  • Sodium-Potassium-Exchanging ATPase/metabolism
  • Cadmium/toxicity*
  • Biological Transport
  • Water Pollutants, Chemical/toxicity*
  • Larva/metabolism
  • Zebrafish/metabolism
  • Zebrafish/physiology*
  • Zebrafish Proteins/metabolism
  • Ions
  • Animals
  • Homeostasis
(all 11)
PubMed
32050336 Full text @ Chemosphere
Abstract
The present study examined the effects of waterborne cadmium (Cd) exposure on ionic balance and ionocyte density in developing zebrafish (Danio rerio) (0-4 days post-fertilization). Fish exposed to 1 or 10 μg Cd/L exhibited an increase in whole body Cd level. Exposure to 10 μg Cd/L also significantly reduced whole body content of Ca2+, but not other major ions (e.g., Na+, K+ and Mg2+). Such reduction was accompanied by a decrease in the density of Ca2+-transporting ionocytes, the Na+/K+-ATPase-rich cells (NaRCs). However, the densities of other ionocyte subtypes (e.g., Na+-transporting ionocytes) remained unchanged after exposure to 10 μg Cd/L. The potential interactive effects between water chemistry and Cd exposure on ionocyte density were examined further in Cd-exposed larvae acclimated to different water NaCl or Ca2+ levels. The results demonstrated that NaRC density increased in fish acclimated to low Ca2+ water, presumably increasing Ca2+ uptake for maintaining Ca2+ homeostasis. However, Cd exposure completely abolished the increased NaRC density in low water Ca2+ environments. The increased NaRCs over development was also reduced in Cd-exposed larvae. In conclusion, our study suggested that Cd exposure reduces the density of NaRCs and suppresses the compensatory regulation of NaRCs during acclimation to low water Ca2+ level. These inhibitory effects by Cd exposure ultimately disrupt Ca2+ balance in the early life stages of zebrafish.
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Citation
Dave, P.H., Kwong, R.W.M. (2020) Cadmium exposure reduces the density of a specific ionocyte subtype in developing zebrafish. Chemosphere. 244:125535.