PUBLICATION
Functional heterogeneity in the pineal projection neurons of zebrafish
- Authors
- Sapède, D., Chaigne, C., Blader, P., Cau, E.
- ID
- ZDB-PUB-200207-31
- Date
- 2020
- Source
- Molecular and cellular neurosciences 103: 103468 (Journal)
- Registered Authors
- Blader, Patrick, Cau, Elise
- Keywords
- Melanopsin, Photoreceptor, Pineal gland, ipRGCs
- MeSH Terms
-
- Animals
- Interneurons/metabolism*
- Neurons/metabolism*
- Photoreceptor Cells/physiology*
- Pineal Gland/metabolism*
- Pineal Gland/pathology
- Signal Transduction/physiology
- Zebrafish/genetics
- PubMed
- 32027966 Full text @ Mol. Cell Neurosci.
Citation
Sapède, D., Chaigne, C., Blader, P., Cau, E. (2020) Functional heterogeneity in the pineal projection neurons of zebrafish. Molecular and cellular neurosciences. 103:103468.
Abstract
The zebrafish pineal organ is a photoreceptive structure containing two main neuronal populations (photoreceptors and projections neurons). Here we describe a subpopulation of projection neurons that expresses the melanopsin gene, opn4xa. This new pineal cell type, that displays characteristics of both projection neurons and photoreceptors, share a similar dependency for BMP and Notch signalling pathways with classical non-photosensitive projection neurons (PN). Functionally, however, whereas classical, opn4xa-negative PNs display an achromatic LIGHT OFF response, the novel cell type we describe exhibit a LIGHT ON character that is elicited by green and blue light. Taken together, our data suggest a previously unanticipated heterogeneity in the projection neuron population in the zebrafish pineal organ raising the question of the importance of these differences in pineal function.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping